ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Spatial Correlations in Natural Scenes Modulate Response Reliability in Mouse Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds.PloS one · 2026Article
- Behavioral techniques for controlling visual stimuli to modulate visual processing in the brain and their implementation in augmented reality technology.Frontiers in neuroscience · 2026Review
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- Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing.bioRxiv : the preprint server for biology · 2025Article
- Stimulus-invariant aspects of the retinal code drive discriminability of natural scenes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
- High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.Neuroscience bulletin · 2024Article
- Modeling the diverse effects of divisive normalization on noise correlations.PLoS computational biology · 2023Article
- Effective and efficient neural networks for spike inference fromCell reports methods · 2023Article
- Binocular visual experience drives the maturation of response variability and reliability in the visual cortex.iScience · 2022Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Statistical neuroscience in the single trial limit.Current opinion in neurobiology · 2021Review
- Stable representation of a naturalistic movie emerges from episodic activity with gain variability.Nature communications · 2021Article
- Temporal stability of stimulus representation increases along rodent visual cortical hierarchies.Nature communications · 2021Article
- Article
- Efficient and robust coding in heterogeneous recurrent networks.PLoS computational biology · 2021Article
- Functional parcellation of mouse visual cortex using statistical techniques reveals response-dependent clustering of cortical processing areas.PLoS computational biology · 2021Article
- Spiking Characteristics of Network-Mediated Responses Arising in Direction-Selective Ganglion Cells of Rabbit and Mouse Retinas to Electric Stimulation for Retinal Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
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2 authors.
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Abstract
Intrinsic neuronal variability significantly limits information encoding in the primary visual cortex (V1). Certain stimuli can suppress this intertrial variability to increase the reliability of neuronal responses. In particular, responses to natural scenes, which have broadband spatiotemporal statistics, are more reliable than responses to stimuli such as gratings. However, very little is known about which stimulus statistics modulate reliable coding and how this occurs at the neural ensemble level. Here, we sought to elucidate the role that spatial correlations in natural scenes play in reliable coding. We developed a novel noise-masking method to systematically alter spatial correlations in natural movies, without altering their edge structure. Using high-speed two-photon calcium imaging in vivo, we found that responses in mouse V1 were much less reliable at both the single neuron and population level when spatial correlations were removed from the image. This change in reliability was due to a reorganization of between-neuron correlations. Strongly correlated neurons formed ensembles that reliably and accurately encoded visual stimuli, whereas reducing spatial correlations reduced the activation of these ensembles, leading to an unreliable code. Together with an ensemble-specific normalization model, these results suggest that the coordinated activation of specific subsets of neurons underlies the reliable coding of natural scenes.
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