ArticleMagnetic resonance in medicine2016
Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Intravoxel Incoherent Motion Magnetic Resonance Imaging with Integrated Slice-specific Shimming for old myocardial infarction: A Pilot Study.Scientific reports · 2019Trial
- Diffusion tensor magnetic resonance imaging of the normal fetal lung: a preliminary report.Pediatric radiology · 2026Article
- Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Consensus Recommendations.Journal of magnetic resonance imaging : JMRI · 2026Article
- The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.Physics in medicine and biology · 2026Review
- Cardiac diffusion kurtosis imaging in the human heart in vivo using 300 mT/m gradients.Magnetic resonance in medicine · 2025Article
- Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.Human brain mapping · 2025Article
- Realistic numerical simulations of diffusion tensor cardiovascular magnetic resonance: The effects of perfusion and membrane permeability.Magnetic resonance in medicine · 2023Article
- Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve.Journal of clinical medicine · 2022Article
- Intravoxel Incoherent Motion Magnetic Resonance Imaging in Skeletal Muscle: Review and Future Directions.Journal of magnetic resonance imaging : JMRI · 2022Review
- Article
- Placenta microstructure and microcirculation imaging with diffusion MRI.Magnetic resonance in medicine · 2018Article
- Simultaneous magnetic resonance diffusion and pseudo-diffusion tensor imaging.Magnetic resonance in medicine · 2018Article
- Evaluation of non-Gaussian diffusion in cardiac MRI.Magnetic resonance in medicine · 2017Article
- Separating blood and water: Perfusion and free water elimination from diffusion MRI in the human brain.NeuroImage · 2017Article
- MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Diffusion tensor imaging and histology of developing hearts.NMR in biomedicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo seek a better understanding of the effect of organized capillary flow on the MR diffusion-weighted signal.
methodsA theoretical framework was proposed to describe the diffusion-weighted MR signal, which was then validated both numerically using a realistic model of capillary network and experimentally in an animal model of isolated perfused heart preparation with myocardial blood flow verified by means of direct arterial spin labeling measurements.
resultsMicrocirculation in organized tissues gave rise to an MR signal that could be described as a combination of the bi-exponential behavior of conventional intravoxel incoherent motion (IVIM) theory and diffusion tensor imaging (DTI) -like anisotropy of the vascular signal, with the flow-related pseudo diffusivity represented as the linear algebraic product between the encoding directional unit vector and an appropriate tensor entity. Very good agreement between theoretical predictions and both numerical and experimental observations were found.
conclusionThese findings suggest that the DTI formalism of anisotropic spin motion can be incorporated into the classical IVIM theory to describe the MR signal arising from diffusion and microcirculation in organized tissues. Magn Reson Med 76:1252-1262, 2016. © 2015 Wiley Periodicals, Inc.
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