ArticleScientific reports2015
Nanoscale volume confinement and fluorescence enhancement with double nanohole aperture.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Purcell gain equalized zero-mode waveguide.Scientific reports · 2024Article
- Fluorescence Enhancement in Topologically Optimized Gallium Phosphide All-Dielectric Nanoantennas.Nano letters · 2024Article
- Nonlocal response of plasmonic core-shell nanotopologies excited by dipole emitters.Nanoscale advances · 2022Article
- The perspectives of broadband metasurfaces and photo-electric tweezer applications.Nanophotonics (Berlin, Germany) · 2022Review
- Enhancing Single-Molecule Fluorescence Spectroscopy with Simple and Robust Hybrid Nanoapertures.ACS photonics · 2021Article
- Synthesizing AgACS omega · 2020Article
- Strong Plasmon Enhancement of the Saturation Photon Count Rate of Single Molecules.The journal of physical chemistry letters · 2020Article
- Overcoming Diffusion-Limited Trapping in Nanoaperture Tweezers Using Opto-Thermal-Induced Flow.Nano letters · 2020Article
- Plasmonics for Biosensing.Materials (Basel, Switzerland) · 2019Review
- Article
- Single-Molecule Plasmon Sensing: Current Status and Future Prospects.ACS sensors · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffraction ultimately limits the fluorescence collected from a single molecule, and sets an upper limit to the maximum concentration to isolate a single molecule in the detection volume. To overcome these limitations, we introduce here the use of a double nanohole structure with 25 nm gap, and report enhanced detection of single fluorescent molecules in concentrated solutions exceeding 20 micromolar. The nanometer gap concentrates the light into an apex volume down to 70 zeptoliter (10(-21) L), 7000-fold below the diffraction-limited confocal volume. Using fluorescence correlation spectroscopy and time-correlated photon counting, we measure fluorescence enhancement up to 100-fold, together with local density of optical states (LDOS) enhancement of 30-fold. The distinctive features of double nanoholes combining high local field enhancement, efficient background screening and relative nanofabrication simplicity offer new strategies for real time investigation of biochemical events with single molecule resolution at high concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.