ArticlePharmaceutical biology2016
Antimicrobial effect of the extracts from Hypericum perforatum against oral bacteria and biofilm formation.
Article in Pharmaceutical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to identify core herb combinations.Frontiers in pharmacology · 2023Pooled it
- Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.BMC veterinary research · 2019Pooled it
- Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial.Clinical and experimental dental research · 2026Trial
- Hyperforin as a Multifunctional Specialized Metabolite of Natural Origin for Chronic Diseases: From Molecular Mechanisms to Clinical Translation.Current issues in molecular biology · 2026Review
- Integrated chemical and biological characterization of Hypericum perforatum extract using LC-MS/MS and in vitro functional assays.Scientific reports · 2026Article
- Polyprenylated Acylphloroglucinols fromPharmaceuticals (Basel, Switzerland) · 2025Article
- Antimicrobial, Anti-Biofilm Activity and Antioxidants of Phenolic Compounds Isolated FromFood science & nutrition · 2025Article
- In Silico Docking of Medicinal Herbs Against P. gingivalis for Chronic Periodontitis Intervention.International dental journal · 2025Article
- Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review.Heliyon · 2024Review
- Evaluation of Microbiological Susceptibility and Long-term Adhesive Properties to Dentin of Primers with Terminalia catappa Linn.The journal of adhesive dentistry · 2024Article
- The In Vitro Assessment of Antibacterial and Antioxidant Efficacy inMicroorganisms · 2023Article
- Cicaderma® in radiation-related dermatitis of breast cancer: Results from the multicentric randomised phase III CICA-RT.Clinical and translational radiation oncology · 2023Article
- Chitosan Membranes Containing Plant Extracts: Preparation, Characterization and Antimicrobial Properties.International journal of molecular sciences · 2023Article
- Outstanding Antibacterial Activity ofLife (Basel, Switzerland) · 2023Article
- The Antimicrobial and Anti-Biofilm Effects ofClinics and practice · 2022Article
- The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application.BioMed research international · 2022Review
- Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in Dentistry.Plants (Basel, Switzerland) · 2021Review
- Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study.Lasers in medical science · 2021Article
- The Influence ofFoods (Basel, Switzerland) · 2021Article
- Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextOne traditional medicines, Hypericum perforatum L. (Hypericaceae), possesses several beneficial effects against depression, ulcers, dyspepsia, abdominal pains, burns, bacterial infections, migraine headaches, and sciatica.
objectiveThe present study investigates the antimicrobial activity of the ethanol extract (HP-EtOH) of H. perforatum and its sub-extracts, namely n-hexane (HP-hexane), chloroform (HP-CHCl3), ethyl acetate (HP-EtOAc), n-butanol (HP-n-BuOH), and water (HP-H2O) extracts, against Streptococcus mutans, S. sobrinus, Lactobacillus plantarum, and Enterococcus faecalis. MATERIALS AND
methodsFor the evaluation of the antimicrobial activity, flowering aerial parts of H. perforatum were extracted with EtOH and then this extract was fractionated to obtain five sub-extracts in different polarities. Antimicrobial activities of HP-EtOH and its sub-extracts against Streptococcus mutans, S. sobrinus, L. plantarum, and E. faecalis were assessed by using colorimetric micro-well dilution at concentration ranges of 64-0.5 μg/ml as well as resazurin microplate and modified microtiter-plate assays between the ranges of 100 and 0.78125 μg/ml.
resultsAccording to the results of the present study, HP-H2O sub-extract displayed strong antibacterial activity (MIC values 8 μg/mL) against S. sobrinus and L. plantarum, and exerted moderate activity against S. mutans and E. faecalis at 32 and 16 μg/mL concentrations, respectively. Other sub-extracts also demonstrated antimicrobial activity against S. sobrinus at a concentration of 16 μg/mL. HP-EtOAc and HP-n-BuOH showed antimicrobial activity against L. plantarum and HP-EtOAc and HP-H2O were also active against E. faecalis at the same concentrations (16 μg/mL).
conclusionAccording to the results, we suggest that H. perforatum could be employed as a natural antibacterial agent in oral care products.
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