ArticleJournal of the American Society of Nephrology : JASN2016
Renal Hemodynamics in AKI: In Search of New Treatment Targets.
Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury.JCI insight · 2025Article
- Preoperative neutrophil percentage-to-albumin ratio as a postoperative AKI predictor in non-cardiac surgery: a retrospective cohort secondary analysis.Scientific reports · 2025Article
- Sphingosine-1-Phosphate Receptor 2 Promotes Renal Microvascular Constriction and Kidney Injury Following Renal Ischemia-Reperfusion in Rats.Function (Oxford, England) · 2025Article
- Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review.BMC nephrology · 2025Review
- Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model.Intensive care medicine experimental · 2025Article
- Article
- Article
- Effect of Respiratory Failure on Peripheral and Organ Perfusion Markers in Severe COVID-19: A Prospective Cohort Study.Journal of clinical medicine · 2024Article
- Renal medullary perfusion differs from that in renal cortex in patients with sepsis associated acute kidney injury and correlates with renal function prognosis: A prospective cohort study.Clinical hemorheology and microcirculation · 2024Article
- Review
- Knockout of the C3a receptor protects against renal ischemia reperfusion injury by reduction of NETs formation.Cellular and molecular life sciences : CMLS · 2023Article
- Contrast-enhanced ultrasonography for identifying acute kidney injury in brain-dead donors.Quantitative imaging in medicine and surgery · 2023Article
- Renal hemodynamic evaluation protocol based on the pathophysiological mechanism of acute kidney injury: Critical Care UltraSound Guided-ARenal failure · 2023Review
- Observational
- Before AKI, renal microcirculation stress may be detected by urine biochemistry. Author's reply.Intensive care medicine · 2022Article
- SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure.World journal of virology · 2022Review
- Central venous pressure and acute kidney injury in critically ill patients with multiple comorbidities: a large retrospective cohort study.BMC nephrology · 2022Observational
- Urine biochemistry assessment in the sequential evaluation of renal function: Time to think outside the box.Frontiers in medicine · 2022Article
- Clinical phenotypes of acute kidney injury are associated with unique outcomes in critically ill septic children.Pediatric research · 2021Observational
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Novel therapeutic interventions are required to prevent or treat AKI. To expedite progress in this regard, a consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 to develop recommendations for research priorities and future directions. Here, we highlight the concepts related to renal hemodynamics in AKI that are likely to reveal new treatment targets on investigation. Overall, we must better understand the interactions between systemic, total renal, and glomerular hemodynamics, including the role of tubuloglomerular feedback. Furthermore, the net consequences of therapeutic maneuvers aimed at restoring glomerular filtration need to be examined in relation to the nature, magnitude, and duration of the insult. Additionally, microvascular blood flow heterogeneity in AKI is now recognized as a common occurrence; timely interventions to preserve the renal microcirculatory flow may interrupt the downward spiral of injury toward progressive kidney failure and should, therefore, be investigated. Finally, development of techniques that permit an integrative physiologic approach, including direct visualization of renal microvasculature and measurement of oxygen kinetics and mitochondrial function in intact tissue in all nephron segments, may provide new insights into how the kidney responds to various injurious stimuli and allow evaluation of new therapeutic strategies.
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