ArticlePharmaceutical biology2016
Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of D-galactose-induced aging mice.
Article in Pharmaceutical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- A Novel Functional Ingredient Derived From a Mixture of Mulberry (Oxidative medicine and cellular longevity · 2026Article
- Polyphenol-rich Morus nigra L. extract mitigates neuroinflammation and cognitive impairment through gut-brain axis modulation in an Alzheimer's disease rat model.Frontiers in pharmacology · 2025Article
- Comprehensive evaluation of frost mulberry leaves of 21 mulberry varieties.Frontiers in plant science · 2025Article
- Multi-Protective Effects of Petunidin-3-O-(International journal of molecular sciences · 2024Article
- Identification, quantification, and antidepressant-like evaluation of anthocyanin-rich extracts from different dietary berries.Food science & nutrition · 2024Article
- Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-α/γ Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7Plants (Basel, Switzerland) · 2022Article
- Phytochemical Composition of Different Botanical Parts ofPlants (Basel, Switzerland) · 2022Review
- Editorial: Application of natural medicinal products in preventing and ameliorating aging-caused cognitive impairment.Frontiers in pharmacology · 2022Article
- Mulberry polyphenol extracts attenuated senescence through inhibition of Ras/ERK via promoting Ras degradation in VSMC.International journal of medical sciences · 2022Article
- Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.Molecular neurobiology · 2021Article
- Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain.Scientific reports · 2021Article
- The Review of Anti-aging Mechanism of Polyphenols onFrontiers in bioengineering and biotechnology · 2021Review
- Effects of Mulberry on The Central Nervous System: A Literature Review.Current neuropharmacology · 2021Review
- Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease.Antioxidants (Basel, Switzerland) · 2019Review
- Nutraceutical Properties of Mulberries Grown in Southern Italy (Apulia).Antioxidants (Basel, Switzerland) · 2019Article
- Pharmacological Properties ofNutrients · 2019Review
- Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose.Scientific reports · 2018Article
- Effects of blackberry (Journal of experimental pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMorus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet.
objectiveThe objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. MATERIALS AND
methodsPhenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, d-galactose, d-galactose + M. nigra 50, and d-galactose + M. nigra 100). Mice were administered d-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver.
resultsIn extract, vanillic (632.093 μg/g) and chlorogenic acids (555.0 μg/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H2O2. Morus nigra significantly improved learning dysfunctions (p < 0.01), increased memory retention (p < 0.01), reduced MDA levels (p < 0.05), and elevated SOD, GPx, and CAT activities (p < 0.05) compared with the d-galactose group. DISCUSSION AND
conclusionThese results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity.
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