ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Sex differences in the blood antioxidant defense system in juvenile rats with various genetic predispositions to hypertension.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effects of salt and stress on blood pressure parameters and antioxidant enzyme function in the heart and aorta of borderline hypertensive rats.Experimental physiology · 2023Article
- Article
- Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs.Cardiovascular toxicology · 2022Article
- Effects of a catechins-enriched diet associated with moderate physical exercise in the prevention of hypertension in spontaneously hypertensive rats.Scientific reports · 2022Article
- Preliminary Findings on the Effect of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles and Acute Stress on Selected Markers of Oxidative Stress in Normotensive and Hypertensive Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR).Clinical science (London, England : 1979) · 2021Review
- Hypotensive and Hepatoprotective Properties of the Polysaccharide-Stabilized Foaming Composition Containing Hydrolysate of Whey Proteins.Nutrients · 2021Article
- (-)-Epicatechin Reduces the Blood Pressure of Young Borderline Hypertensive Rats During the Post-Treatment Period.Antioxidants (Basel, Switzerland) · 2020Article
- Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases.European journal of nutrition · 2018Review
- Chronic Stress Produces Persistent Increases in Plasma Corticosterone, Reductions in Brain and Cardiac Nitric Oxide Production, and Delayed Alterations in Endothelial Function in Young Prehypertensive Rats.Frontiers in physiology · 2018Article
- Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains.Archives of biochemistry and biophysics · 2017Article
- Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension.Redox report : communications in free radical research · 2017Article
- The NOX2-derived reactive oxygen species damaged endothelial nitric oxide system via suppressed BKCa/SKCa in preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- The activation of the kynurenine pathway in a rat model with renovascular hypertension.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Do Sex Differences in Respiratory Burst Enzyme Activities Exist in Human Immunodeficiency Virus-1 Infection?Medical sciences (Basel, Switzerland) · 2016Article
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9 authors.
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Abstract
This study investigated the contribution of blood oxidative stress (OS) to the development of hypertension, as well as sex differences in the antioxidant defense system (ADS) in genetic models of hypertension. Nine-week-old normotensive Wistar-Kyoto (WKY) rats, borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR) of both sexes were used. Systolic blood pressure (SBP) was determined by tail-cuff plethysmography, the trolox equivalent antioxidant capacity (TEAC) and the concentration of lipid peroxides (LP) were determined in plasma. The activity of the antioxidant enzymes Cu/Zn-superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) was determined in erythrocytes. SBP was significantly elevated in BHR and SHR in both sexes. BHR and SHR males had a higher SBP than the respective females. Sex-dependent differences in the ADS were found only in SHR, in which TEAC, SOD and CAT were significantly higher in males than in females. No differences in TEAC, SOD, CAT and GPx were observed between BHR (males and females) and WKY controls. LP levels were similar in all the groups investigated. Significant positive correlations were observed between SBP and both SOD and CAT. TEAC correlated positively with SOD and LP. As no signs of oxidative damage to lipids were found in young BHR and SHR of either sex, OS in the blood does not seem to be causatively related to the development of hypertension in these rats. However, despite activated antioxidant defenses, the positive correlation between plasma TEAC and LP suggests that oxidative damage is progressing slowly and therefore it seems to be a consequence rather than the cause of hypertension.
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