ArticleMolecular genetics and genomics : MGG2016
Genome-wide identification and characterization of the apple (Malus domestica) HECT ubiquitin-protein ligase family and expression analysis of their responsiveness to abiotic stresses.
Article in Molecular genetics and genomics : MGG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 36 citations in OpenAlex.
- Haplotype-phased 'Ottawa 3' genome unravels differential reaction of apple rootstock roots to mixed viral infection.The Plant journal : for cell and molecular biology · 2026Article
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- Genome-Wide Analysis of HECT E3 Ligases Members inInternational journal of molecular sciences · 2024Article
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Expression Profiling Reveals the Possible Involvement of the Ubiquitin-Proteasome Pathway in Abiotic Stress Regulation inInternational journal of molecular sciences · 2023Article
- HECT ubiquitin ligases as accessory proteins of the plant proteasome.Essays in biochemistry · 2022Article
- Genome-wide analysis of HECT E3 ubiquitin ligase gene family in Solanum lycopersicum.Scientific reports · 2021Article
- Genome-wide identification and expression analysis of the trehalose-6-phosphate synthase (PeerJ · 2021Article
- Genome-wide analysis ofPeerJ · 2021Article
- Growth, physiological and transcriptomic analysis of the perennial ryegrassRoyal Society open science · 2020Article
- Genome-wide identification, phylogenetic and expression analysis of the maize HECT E3 ubiquitin ligase genes.Genetica · 2019Article
- Article
- Comprehensive Genomic Survey, Characterization and Expression Analysis of the HECT Gene Family inGenes · 2019Article
- Article
- Two-State Co-Expression Network Analysis to Identify Genes Related to Salt Tolerance in Thai rice.Genes · 2018Article
- SorghumFDB: sorghum functional genomics database with multidimensional network analysis.Database : the journal of biological databases and curation · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitin-protein ligases (E3s) directly participate in ubiquitin (Ub) transferring to the target proteins in the ubiquitination pathway. The HECT ubiquitin-protein ligase (UPL), one type of E3s, is characterized as containing a conserved HECT domain of approximately 350 amino acids in the C terminus. Some UPLs were found to be involved in trichome development and leaf senescence in Arabidopsis. However, studies on plant UPLs, such as characteristics of the protein structure, predicted functional motifs of the HECT domain, and the regulatory expression of UPLs have all been limited. Here, we present genome-wide identification of the genes encoding UPLs (HECT gene) in apple. The 13 genes (named as MdUPL1-MdUPL13) from ten different chromosomes were divided into four groups by phylogenetic analysis. Among these groups, the encoding genes in the intron-exon structure and the included additional functional domains were quite different. Notably, the F-box domain was first found in MdUPL7 in plant UPLs. The HECT domain in different MdUPL groups also presented different spatial features and three types of conservative motifs were identified. The promoters of each MdUPL member carried multiple stress-response related elements by cis-acting element analysis. Experimental results demonstrated that the expressions of several MdUPLs were quite sensitive to cold-, drought-, and salt-stresses by qRT-PCR assay. The results of this study helped to elucidate the functions of HECT proteins, especially in Rosaceae plants.
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