ArticleBiology letters2015
Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance.
Article in Biology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Mitochondrial Haplogroups Influence Mitochondrial Structure and Function, Oxidative Stress, Autophagy, and Lipid Metabolism of Chicken Hepatocytes in Response to Energy Stimulation.Animals : an open access journal from MDPI · 2026Article
- Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.Journal of molecular biology · 2025Article
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
- Article
- Origin and spatial population structure of Malagasy native chickens based on mitochondrial DNA.Scientific reports · 2024Article
- Article
- Unveiling new perspective of phylogeography, genetic diversity, and population dynamics of Southeast Asian and Pacific chickens.Scientific reports · 2022Article
- Occasional paternal inheritance of the germline-restricted chromosome in songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Insights into the Mitochondrial and Nuclear Genome Diversity of Two High Yielding Strains of Laying Hens.Animals : an open access journal from MDPI · 2021Article
- The effect of mitochondrial DNA polymorphisms on cattle reproduction.Molecular biology reports · 2021Article
- Population Genetic Structure and Contribution of Philippine Chickens to the Pacific Chicken Diversity Inferred From Mitochondrial DNA.Frontiers in genetics · 2021Article
- The maternal origin of indigenous domestic chicken from the Middle East, the north and the horn of Africa.BMC genetics · 2020Article
- High incidence of heteroplasmy in the mtDNA of a natural population of the spider crab Maja brachydactyla.PloS one · 2020Article
- Sexual conflict through mother's curse and father's curse.Theoretical population biology · 2019Article
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Paternal comeback in mitochondrial DNA inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The sperm factor: paternal impact beyond genes.Heredity · 2018Review
- Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens.BMC genomics · 2017Article
- MaGelLAn 1.0: a software to facilitate quantitative and population genetic analysis of maternal inheritance by combination of molecular and pedigree information.Genetics, selection, evolution : GSE · 2016Article
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Authors and funding
13 authors at 8 institutions in 6 countries.
Funding
Abstract
Mitochondrial genomes represent a valuable source of data for evolutionary research, but studies of their short-term evolution have typically been limited to invertebrates, humans and laboratory organisms. Here we present a detailed study of 12 mitochondrial genomes that span a total of 385 transmissions in a well-documented 50-generation pedigree in which two lineages of chickens were selected for low and high juvenile body weight. These data allowed us to test the hypothesis of time-dependent evolutionary rates and the assumption of strict maternal mitochondrial transmission, and to investigate the role of mitochondrial mutations in determining phenotype. The identification of a non-synonymous mutation in ND4L and a synonymous mutation in CYTB, both novel mutations in Gallus, allowed us to estimate a molecular rate of 3.13 × 10(-7) mutations/site/year (95% confidence interval 3.75 × 10(-8)-1.12 × 10(-6)). This is substantially higher than avian rate estimates based upon fossil calibrations. Ascertaining which of the two novel mutations was present in an additional 49 individuals also revealed an instance of paternal inheritance of mtDNA. Lastly, an association analysis demonstrated that neither of the point mutations was strongly associated with the phenotypic differences between the two selection lines. Together, these observations reveal the highly dynamic nature of mitochondrial evolution over short time periods.
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