Evidence map›Paper›PMID 26510574›Full record

Trial reportLasers in medical science2016

Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial.

Rubia Garcia Lopes, Ana Carolina Costa da Mota, Carolina Soares, Olinda Tarzia, Alessandro Melo Deana, Renato Araújo Prates, Cristiane Miranda França, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita Ferrari, Sandra Kalil Bussadori

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02007993 (Photodynamic Therapy as Novel Treatment for Halitosis in Adolescents), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02007993 naunknown statusnot on this map

Photodynamic Therapy as Novel Treatment for Halitosis in Adolescents: Crontolled Clinical Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2013 to 2014Enrolled130ConditionsHalitosisArmsPDT, Tongue Scraper
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rubia Garcia LopesBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Ana Carolina Costa da MotaBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Carolina SoaresCenter of Excellence in the Treatment of Halitosis, São Paulo, Brazil.
Olinda TarziaCenter of Excellence in the Treatment of Halitosis, São Paulo, Brazil.
Alessandro Melo DeanaBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Renato Araújo PratesBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Cristiane Miranda FrançaBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Kristianne Porta Santos FernandesBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Raquel Agnelli Mesquita FerrariBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil.
Sandra Kalil BussadoriBiophotonics Applied to Science Health Post Graduation Program, Nove de Julho University, São Paulo, Brazil. sandra.skb@gmail.com.
Universidade Nove de Julho · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledLight with or without chemical agents has been used to induce therapeutic and antimicrobial effects. With photodynamic therapy, the antimicrobial effect is confined to areas covered by a photosensitive dye and irradiated with light. The aim of the present study was to evaluate the effect of photodynamic therapy for the treatment of halitosis in adolescents through the analysis of volatile sulfur compounds, especially sulfide. A controlled, clinical trial was conducted with 45 adolescents randomly allocated to three groups: group 1, photodynamic therapy administered to the dorsum of the tongue; group 2, treatment with a tongue scraper; and group 3, treatment with a tongue scraper combined with photodynamic therapy. The diagnosis of halitosis was performed using gas chromatography before and after treatment. Comparisons were made using the Kruskal-Wallis test followed by the Student-Newman-Keuls test, with the level of significance set at 5 % (p < 0.05). After treatment, a statistically significant reduction in halitosis was found in all groups (p < 0.001). The greatest reduction in total sulfides (median = 0) occurred with the combination of tongue scraper and photodynamic therapy. The present study describes a novel option for the treatment of halitosis in adolescents with an immediate effect that does not involve the mechanical aggression of the lingual papillae that occurs with conventional treatment.

trial registrationPhotodynamic Therapy in Adolescents Halitosis ( https://clinicaltrials.gov/ct2/show/NCT02007993?term=NCT02007993&rank=1 )Number: NCT02007993FUNDING:FAPESPNumber: 2013/13032-8.

Indexed as

PhotochemotherapyAdolescentFemaleHalitosisHumansMaleSulfidesTongueTreatment OutcomeSulfidesHalitosisLaserPhotodynamic therapyTongue

Identifiers

PMID26510574
OpenAlexW2211950674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.