ArticleWorld journal of surgery2016
Does Lymphadenectomy Improve Survival in Patients with Adrenocortical Carcinoma? A Population-Based Study.
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Surgical therapy of adrenal tumors: guidelines from the German Association of Endocrine Surgeons (CAEK).Langenbeck's archives of surgery · 2019Guideline
- Posterior retroperitoneoscopic adrenalectomy (PRA) in adrenocortical carcinoma (ACC).Langenbeck's archives of surgery · 2025Article
- Bridging the Scientific Gaps to Identify Effective Treatments in Adrenocortical Cancer.Cancers · 2022Review
- Review
- Article
- Comparative performances of nomograms and conditional survival after resection of adrenocortical cancer.BJS open · 2021Observational
- Positive Lymph Nodes in Adrenocortical Carcinoma: What Does It Mean?World journal of surgery · 2021Article
- The challenge to differentiate between sarcoma or adrenal carcinoma-an observational study.Rare tumors · 2021Article
- Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment.Therapeutic advances in chronic disease · 2021Review
- American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020Review
- [Surgery of adrenal diseases].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Article
- Comparative Performance of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Manual for Adrenocortical Carcinoma.World journal of surgery · 2020Article
- [Resection strategies for adrenocortical carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Review
- [Surgical strategies for non-metastatic adrenocortical carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group.Annals of surgical oncology · 2018Article
- Nomograms to predict overall survival and cancer-specific survival in patients with adrenocortical carcinoma.Cancer management and research · 2018Article
- Prognostic Factors of Adrenocortical Carcinoma: An Analysis of the Surveillance Epidemiology and End Results (SEER) DatabaseAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Primary site surgery for metastatic adrenocortical carcinoma improves survival outcomes: an analysis of a population-based database.OncoTargets and therapy · 2017Article
- Actual 10-year survivors following resection of adrenocortical carcinoma.Journal of surgical oncology · 2016Article
- Lymphadenectomy for Adrenocortical Carcinoma: Is There a Therapeutic Benefit?Annals of surgical oncology · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent study suggested a survival benefit in patients with adrenocortical carcinoma (ACC) who had undergone lymphadenectomy. The objective of this study was to study the effect of lymphadenectomy on the survival rates of patients with ACC.
methodsData from adult patients with histology-proven ACC from the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 Registries (1973-2011) were analyzed to assess the impact of lymphadenectomy (≥4 lymph nodes removed) on disease-specific survival (DSS).
resultsOf 1525 patients with ACC, 45% were male. 36, 20, and 44% of patients presented with localized, regional, and distant metastatic diseases, respectively. 8% of patients (n = 67/802) underwent lymphadenectomy. We observed a higher rate of lymphadenectomy performed in patients with regional disease [locally advanced tumors (stage T3 and T4) and/or lymph node metastasis] and distant metastasis than in those with localized tumors (12.4% and 12.0 vs. 5.1, respectively, p < 0.01) and in patients with primary tumor sizes >10 cm (12.4 vs. 4.2 %, p < 0.01). Lymph node metastasis was present in 12.8% (19.2% in locally advanced ACC). A lymphadenectomy was not associated with improved DSS on univariate analysis (p = 0.30), regardless of tumor size or staging. Independent prognostic factors included: ages ≥60 years (p < 0.01, HR 1.70), lymph node metastasis (p < 0.01, HR 1.7), distant metastasis (p < 0.01, HR 5.6), complete resection of tumor (p < 0.01, HR 0.47), and debulking surgery (p < 0.01, HR 0.49).
conclusionA lymphadenectomy is not commonly performed in patients with ACC in the U.S. Although we found no survival benefit in this cohort with a low rate of lymphadenectomy, a lymphadenectomy may be considered in patients with locally advanced tumors (T3 and T4) due to a higher rate of lymph node metastasis.
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