ArticleAngewandte Chemie (International ed. in English)2015
Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03311191 (Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin
Who cites it
21 citing papers in PubMed.
- Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery.Biosensors & bioelectronics · 2024Article
- Flap Monitoring Techniques: A Review.Journal of clinical medicine · 2024Review
- Versatile, in-line optical oxygen tension sensors for continuous monitoring duringSensors & diagnostics · 2024Article
- Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenationJournal of photochemistry and photobiology · 2024Article
- Autologous porcine VRAM flap model for VCA research.Frontiers in transplantation · 2024Article
- Recent advances in biosensors for real time monitoring of pH, temperature, and oxygen in chronic wounds.Materials today. Bio · 2023Review
- Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor.Scientific reports · 2023Article
- Calculation of Tissue Oxygenation via an Inverse Boundary Problem for Transcutaneous Oxygenation Wearable Applications.ACS measurement science au · 2023Article
- Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle.Molecular metabolism · 2021Review
- Difluoroboron β-diketonate polylactic acid oxygen nanosensors for intracellular neuronal imaging.Scientific reports · 2021Article
- NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion.Transfusion medicine reviews · 2021Review
- Wearable device for remote monitoring of transcutaneous tissue oxygenation.Biomedical optics express · 2020Article
- A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction.Science advances · 2020Article
- Temperature Sensing in Cells Using Polymeric Upconversion Nanocapsules.Biomacromolecules · 2020Article
- Early visualization of skin burn severity using a topically applied dye-loaded liquid bandage.Scientific reports · 2020Article
- Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages.Journal of biomedical optics · 2018Article
- Polystyrene Oxygen Optodes Doped with Ir(III) and Pd(II) meso-Tetrakis(pentafluorophenyl)porphyrin Using an LED-Based High-Sensitivity Phosphorimeter.Sensors (Basel, Switzerland) · 2018Article
- Non-invasive monitoring of skin inflammation using an oxygen-sensing paint-on bandage.Biomedical optics express · 2017Article
- Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution.Journal of the American Chemical Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A new group of "clickable" and brightly emissive metalloporphyrins has been developed for the visualization of oxygenation under ambient light with the naked eye. These alkynyl-terminated compounds permit the rapid and facile synthesis of oxygen-sensing dendrimers through azide-alkyne click chemistry. With absorption maxima overlapping with the wavelengths of common commercial laser sources, they are readily applicable to biomedical imaging of tissue oxygenation. An efficient synthetic methodology, featuring the stable trimethylacetyl (pivaloyl) protecting group, is described for their preparation. A paint-on liquid bandage containing a new, click-synthesized porphyrin dendrimer has been used to map oxygenation across an ex vivo porcine skin burn model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.