Evidence map›Paper›PMID 26510531›Full record

ReviewHuman genomics2015

A survey of computational tools for downstream analysis of proteomic and other omic datasets.

Anis Karimpour-Fard, L Elaine Epperson, Lawrence E Hunter

Abstract readReview
In one paragraph

Review in Human genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Biological mechanisms underlying the ossification of ligamentum flavum and potential therapeutic targets derived from current research.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anis Karimpour-FardDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. anis.karimpour-fard@ucdenver.edu.
L Elaine EppersonIntegrated Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206, USA.
Lawrence E HunterDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Funding

Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
Technology Development for a MolBio Knowledge-BaseR01LM008111 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2004 to 2021
$9.7M
Bio Text NLPR01LM009254 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2006 to 2018
$5.9M
NLM NIH HHS 2R01LM008111NLM NIH HHS 2R01LM009254NLM NIH HHS R01 LM008111NLM NIH HHS R01 LM009254NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

Proteomics is an expanding area of research into biological systems with significance for biomedical and therapeutic applications ranging from understanding the molecular basis of diseases to testing new treatments, studying the toxicity of drugs, or biotechnological improvements in agriculture. Progress in proteomic technologies and growing interest has resulted in rapid accumulation of proteomic data, and consequently, a great number of tools have become available. In this paper, we review the well-known and ready-to-use tools for classification, clustering and validation, interpretation, and generation of biological information from experimental data. We suggest some rules of thumb for the reader on choosing the best suitable learning method for a particular dataset and conclude with pathway and functional analysis and then provide information about submitting final results to a repository.

Indexed as

ProteomicsSoftwareCluster AnalysisComputational BiologyDatabases, GeneticHumans

Identifiers

PMID26510531
PMCPMC4624643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.