ArticleVeterinary research2015
The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an estrous cycle.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Unraveling the relationship between the vaginal microbiome and return to estrus in post-weaning sows.BMC veterinary research · 2026Article
- Relationship between the composition of vaginal bacterial populations and the reproductive stage in captive collared peccaries.Reproduction & fertility · 2025Article
- Bacterial profiles of the oral, vaginal, and rectal mucosa and colostrum of periparturient sows.PloS one · 2025Article
- Vaginal and Uterine Microbiota of Healthy Maiden Mares during Estrus.Veterinary sciences · 2024Article
- Reproductive Tract Microbiota of Mares.Veterinary sciences · 2024Review
- Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model.NPJ biofilms and microbiomes · 2023Article
- Oropharyngeal, proximal colonic, and vaginal microbiomes of healthy Korean native black pig gilts.BMC microbiology · 2023Article
- Intestinal microbial diversity in female rhesus (Frontiers in microbiology · 2022Article
- Vaginal Microbiota Diversity in Response to Lipopolysaccharide in Gilts Housed Under Three Housing Systems.Frontiers in genetics · 2022Article
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Vaginal microbiome and serum metabolite differences in late gestation commercial sows at risk for pelvic organ prolapse.Scientific reports · 2021Article
- Gut and Vagina Microbiota Associated With Estrus Return of Weaning Sows and Its Correlation With the Changes in Serum Metabolites.Frontiers in microbiology · 2021Article
- Vaginal Microbiota Is Stable throughout the Estrous Cycle in Arabian Maress.Animals : an open access journal from MDPI · 2020Article
- Bacterial communities associated to the urethra of healthy gilts and pregnant sows undergoing different reproductive protocols.Journal of animal science · 2020Article
- An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy.EBioMedicine · 2020Article
- The rodent vaginal microbiome across the estrous cycle and the effect of genital nerve electrical stimulation.PloS one · 2020Article
- Temporal analysis of vaginal proteome reveals developmental changes in lower reproductive tract of gilts across the first two weeks postnatal.Scientific reports · 2019Article
- Characterization of microbial communities in the chicken oviduct and the origin of chicken embryo gut microbiota.Scientific reports · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the pig has been introduced as an advanced animal model of genital tract infections in women, almost no knowledge exists on the porcine vaginal microbiota, especially in barrier-raised Göttingen Minipigs. In women, the vaginal microbiota plays a crucial role for a healthy vaginal environment and the fate of sexually transmitted infections such as Chlamydia trachomatis infections. Therefore, knowledge on the vaginal microbiota is urgently needed for the minipig model. The aim of this study was to characterize the microbiota of the anterior vagina by 16 s rRNA gene sequencing in prepubertal and sexually mature Göttingen Minipigs during an estrous cycle. The dominating phyla in the vaginal microbiota consisted of Firmicutes, Proteobacteria, Actinobacteria, Bacteriodetes and Tenericutes. The most abundant bacterial families were Enterobacteriaceae, unclassified families from Gammaproteobacteria, Clostridiales Family XI Incertae Sedis, Paenibacillaceae, Lactobacillaceae, Ruminococcaceae and Syntrophaceae. We found a higher abundance of Lactobacillaceae in the prepubertal Göttingen Minipigs compared to sexually mature non-pregnant Göttingen Minipigs. However, correlation tests and diversity parameters revealed a very stable vaginal microbiota in the Göttingen Minipigs, both before and after sexual maturity and on different days throughout an estrous cycle. The vaginal microbiota in Göttingen Minipigs was not dominated by lactobacilli, as it is in women and according to our results the minipig vaginal microbiota is very stable, in opposite to women. These differences should be considered when using the minipig as a model of the genital tract in women.
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