ArticleHuman brain mapping2016
Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Brain imaging and behavior · 2019Pooled it
- Computational modeling of reversal learning impairments in schizophrenia and bipolar disorder reveals shared failure to exploit rewards.Journal of psychopathology and clinical science · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia.BMC psychiatry · 2023Article
- Cumulative Genetic Score of DRD2 Polymorphisms Is Associated with Impulsivity and Masked Semantic Priming.Journal of molecular neuroscience : MN · 2022Article
- Differential Effects of Psychotic Illness on Directed and Random Exploration.Computational psychiatry (Cambridge, Mass.) · 2020Article
- Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.Schizophrenia bulletin · 2019Article
- Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.Nature communications · 2019Article
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- MRI Indices of Cortical Development in Young People With Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms.Schizophrenia bulletin · 2019Article
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Preliminary evidence for genetic overlap between body mass index and striatal reward response.Translational psychiatry · 2018Article
- Polygenic Risk of Spasmodic Dysphonia is Associated With Vulnerable Sensorimotor Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Evidence of absence: no relationship between behaviourally measured prediction error response and schizotypy.Cognitive neuropsychiatry · 2017Article
- Further support for association between GWAS variant for positive emotion and reward systems.Translational psychiatry · 2017Article
- Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NeuroImage. Clinical · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total of common risk variants weighted by their effect. Previous studies suggest that schizophrenia RPS predict alterations to neural networks that support working memory and verbal fluency. In this study, we apply schizophrenia RPS to fMRI data to elucidate the effects of polygenic risk on functional brain networks during a probabilistic-learning neuroimaging paradigm. The neural networks recruited during this paradigm have previously been shown to be altered to unmedicated schizophrenia patients and relatives of schizophrenia patients, which may reflect genetic susceptibility. We created schizophrenia RPS using summary data from the Psychiatric Genetic Consortium (Schizophrenia Working Group) for 83 healthy individuals and explore associations between schizophrenia RPS and blood oxygen level dependency (BOLD) during periods of choice behavior (switch-stay) and reflection upon choice outcome (reward-punishment). We show that schizophrenia RPS is associated with alterations in the frontal pole (PWHOLE-BRAIN-CORRECTED = 0.048) and the ventral striatum (PROI-CORRECTED = 0.036), during choice behavior, but not choice outcome. We suggest that the common risk variants that increase susceptibility to schizophrenia can be associated with alterations in the neural circuitry that support the processing of changing reward contingencies. Hum Brain Mapp 37:491-500, 2016. © 2015 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.