ArticlePloS one2015
Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression.BMJ global health · 2025Pooled it
- Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Clinical predictors of poor outcome of bacterial meningitis in infants less than 90 days: a systematic review.Frontiers in pediatrics · 2024Pooled it
- TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis.Epidemiology and infection · 2020Pooled it
- Development and internal validation of a prognostic nomogram for poor outcomes in neonatal bacterial meningitis.Translational pediatrics · 2026Article
- Article
- Early prognostic value of repeat CSF parameter measurements in neonatal bacterial meningitis following initial antimicrobial therapy.Italian journal of pediatrics · 2025Article
- May bacterial meningitis pave the way for a toxoplasmosis flare-up: a cross-sectional study from Egypt.BMC infectious diseases · 2025Article
- Paediatric cranial ultrasound: abnormalities of the brain in term neonates and young infants.Insights into imaging · 2025Article
- Time to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia.BMC infectious diseases · 2025Article
- Identifying the need for surgical intervention in pediatric bacterial meningitis: single-center experience.Frontiers in pediatrics · 2025Article
- The evaluation of antimicrobial stewardship for bacterial meningitis in neonates.Pediatric discovery · 2024Article
- Case report: an infant with late-onset meningitis caused by Escherichia coli.GMS hygiene and infection control · 2024Article
- The clinical condition rather than cerebrospinal fluid levels may guide the optimal duration of antimicrobial therapy among neonates with bacterial meningitis: A single-center retrospective study.Pediatric discovery · 2023Article
- Neonatal Brain Abscess withAntibiotics (Basel, Switzerland) · 2023Article
- Antibacterial efficacy of synthesized silver nanoparticles of Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O) against biofilm forming meningitis causing microbes.Scientific reports · 2023Article
- A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates.EBioMedicine · 2023Article
- Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway.BMC infectious diseases · 2022Article
- Establishment of a predictive model for purulent meningitis in preterm infants.Translational pediatrics · 2022Article
- High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children.Frontiers in immunology · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonates are at high risk of meningitis and of resulting neurologic complications. Early recognition of neonates at risk of poor prognosis would be helpful in providing timely management. From January 2008 to June 2014, we enrolled 232 term neonates with bacterial meningitis admitted to 3 neonatology departments in Shanghai, China. The clinical status on the day of discharge from these hospitals or at a postnatal age of 2.5 to 3 months was evaluated using the Glasgow Outcome Scale (GOS). Patients were classified into two outcome groups: good (167 cases, 72.0%, GOS = 5) or poor (65 cases, 28.0%, GOS = 1-4). Neonates with good outcome had less frequent apnea, drowsiness, poor feeding, bulging fontanelle, irritability and more severe jaundice compared to neonates with poor outcome. The good outcome group also had less pneumonia than the poor outcome group. Besides, there were statistically significant differences in hemoglobin, mean platelet volume, platelet distribution width, C-reaction protein, procalcitonin, cerebrospinal fluid (CSF) glucose and CSF protein. Multivariate logistic regression analyses suggested that poor feeding, pneumonia and CSF protein were the predictors of poor outcome. CSF protein content was significantly higher in patients with poor outcome. The best cut-offs for predicting poor outcome were 1,880 mg/L in CSF protein concentration (sensitivity 70.8%, specificity 86.2%). After 2 weeks of treatment, CSF protein remained higher in the poor outcome group. High CSF protein concentration may prognosticate poor outcome in neonates with bacterial meningitis.
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