Evidence map›Paper›PMID 26509871›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Is Exposure to Famine in Childhood and Economic Development in Adulthood Associated With Diabetes?

Ningjian Wang, Xiaojin Wang, Bing Han, Qin Li, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Chaoxia Zhu and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
25.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Ningjian WangInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Xiaojin WangInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Bing HanInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Qin LiInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Yi ChenInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Chunfang ZhuInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Yingchao ChenInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Fangzhen XiaInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Zhen CangInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Chaoxia ZhuInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Meng LuInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Ying MengInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Chi ChenInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Dongping LinInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Bingshun WangInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Michael D JensenInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Yingli LuInstitute and Department of Endocrinology and Metabolism (N.W., B.H., Q.L., Yi.C., C.Z., Yin.C., F.X., M.L., Y.M., C.C., D.L., Y.L.), Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Department of Biostatistics (X.W., B.W.), Shanghai JiaoTong University School of Medicine, Shanghai 200025, China; and Endocrine Research Unit (M.D.J.), Mayo Clinic, Rochester, Minnesota 55905.
Shanghai Ninth People's Hospital · CNShanghai Jiao Tong University · CNMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 in 2013. We hypothesize that these two events are associated with the booming rate of diabetes in China.

objectiveWe aimed to explore whether exposure to famine in early life and high economic status in adulthood was associated with diabetes in later life. DESIGN AND

settingOur data of 6897 adults were from a cross-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014. Among them, 3844 adults experienced famine during different life stages and then lived in areas with different economic statuses in adulthood.

main outcome measureDiabetes was considered as fasting plasma glucose of 7.0 mmol/L or greater, hemoglobin A1c of 6.5% or greater, and/or a previous diagnosis by health care professionals.

resultsCompared with nonexposed subjects, famine exposure during the fetal period (odds ratio [OR]1.53, 95% confidence interval [CI]1.09-2.14) and childhood (OR 1.82, 95% CI 1.21-2.73) was associated with diabetes after adjusting for age and gender. Further adjustments for adiposity, height, the lipid profile, and blood pressure did not significantly attenuate this association. Subjects living in areas with high economic status had a greater diabetes risk in adulthood (OR 1.46, 95% CI 1.20-1.78). In gender-specific analyses, fetal-exposed men (OR 1.64, 95% CI, 1.04-2.59) and childhood-exposed women (OR 2.81, 95% CI, 1.59-4.97) had significantly greater risk of diabetes.

conclusionsThe rapid increase in the prevalence of diabetes in middle-aged and elderly people in China is associated with the combination of exposure to famine during the fetal stage and childhood and high economic status in adulthood. Our findings may partly explain the booming diabetes phenomenon in China.

Indexed as

Economic DevelopmentAdiposityAdultAge FactorsBlood PressureBody HeightChildChinaCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHealth SurveysHumansLipidsPregnancyGlycated HemoglobinLipids

Identifiers

PMID26509871
PMCPMC4667167
OpenAlexW1845713583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.