ArticlePloS one2015
Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Increased interleukin-6 levels are associated with atrioventricular conduction delay in severe COVID-19 patients.Journal of arrhythmia · 2024Article
- Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Pathophysiology of CaFrontiers in physiology · 2023Review
- Atrioventricular node dysfunction in pressure overload-induced heart failure-Involvement of the immune system and transcriptomic remodelling.Frontiers in pharmacology · 2023Article
- In-hospital Outcomes and Arrhythmia Burden in Patients with Obstructive Sleep Apnea and Heart Failure with Preserved Ejection Fraction.The Journal of innovations in cardiac rhythm management · 2022Article
- Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit.Circulation. Heart failure · 2021Article
- Symptomatic sinus bradycardia due to electrolyte imbalances in syndrome of inappropriate antidiuretic hormone (SIADH) related covid-19: a case report.BMC infectious diseases · 2021Article
- Correlation between septal midwall late gadolinium enhancement on CMR and conduction delay on ECG in patients with nonischemic dilated cardiomyopathy.International journal of cardiology. Heart & vasculature · 2020Article
- Review
- Atrioventricular conduction defect associated with severe hyponatremia.Clujul medical (1957) · 2018Article
- Dickkopf‑3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure.Molecular medicine reports · 2018Article
- Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling.Scientific reports · 2017Article
- Reverse electrical remodeling following pressure unloading in a rat model of hypertension-induced left ventricular myocardial hypertrophy.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling.Journal of molecular and cellular cardiology · 2016Article
- Electrocardiogram manifestations of hyponatraemia.Cardiovascular journal of AfricaArticle
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Heart failure is a major killer worldwide. Atrioventricular conduction block is common in heart failure; it is associated with worse outcomes and can lead to syncope and bradycardic death. We examine the effect of heart failure on anatomical and ion channel remodelling in the rabbit atrioventricular junction (AVJ). Heart failure was induced in New Zealand rabbits by disruption of the aortic valve and banding of the abdominal aorta resulting in volume and pressure overload. Laser micro-dissection and real-time polymerase chain reaction (RT-PCR) were employed to investigate the effects of heart failure on ion channel remodelling in four regions of the rabbit AVJ and in septal tissues. Investigation of the AVJ anatomy was performed using micro-computed tomography (micro-CT). Heart failure animals developed first degree heart block. Heart failure caused ventricular myocardial volume increase with a 35% elongation of the AVJ. There was downregulation of HCN1 and Cx43 mRNA transcripts across all regions and downregulation of Cav1.3 in the transitional tissue. Cx40 mRNA was significantly downregulated in the atrial septum and AVJ tissues but not in the ventricular septum. mRNA abundance for ANP, CLCN2 and Navβ1 was increased with heart failure; Nav1.1 was increased in the inferior nodal extension/compact node area. Heart failure in the rabbit leads to prolongation of the PR interval and this is accompanied by downregulation of HCN1, Cav1.3, Cx40 and Cx43 mRNAs and anatomical enlargement of the entire heart and AVJ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.