Evidence map›Paper›PMID 26509462›Full record

GuidelineLiver international : official journal of the International Association for the Study of the Liver2016

HCV Council--critical appraisal of data: recommendations for clinical practice in a rapidly evolving therapeutic landscape.

Nancy Reau, Michael W Fried, David R Nelson, Robert S Brown, Gregory T Everson, Stuart C Gordon, Ira M Jacobson, Joseph K Lim, Paul J Pockros, K Rajender Reddy and 1 more

Abstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Liver international : official journal of the International Association for the Study of the Liver, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. HCV Council--critical appraisal of data: recommendations for clinical practice in a rapidly evolving therapeutic landscape.Liver international : official journal of the International Association for the Study of the Liver · 2016
    Guideline
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nancy ReauRush University Medical Center, Chicago, IL, USA.
Michael W FriedUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David R NelsonUniversity of Florida, Gainesville, FL, USA.
Robert S BrownWeill Cornell Medical College, New York, NY, USA.
Gregory T EversonUniversity of Colorado, Aurora, CO, USA.
Stuart C GordonHenry Ford Medical Center, Detroit, MI, USA.
Ira M JacobsonWeill Cornell Medical College, New York, NY, USA.
Joseph K LimYale University School of Medicine, New Haven, CT, USA.
Paul J PockrosScripps Translational Science Institute, La Jolla, CA, USA.
K Rajender ReddyUniversity of Pennsylvania, Philadelphia, PA, USA.
Kenneth E ShermanUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NCATS NIH HHS UL1 TR001427
6 · The paper itself

Abstract

BACKGROUND &

aimsHCV Council 2014, like its predecessor HCV Council 2011, assembled leading clinicians and researchers in the field of hepatitis C to critically evaluate current data regarding best practices for managing patients with chronic hepatitis C virus (HCV).

methodsClinical practice statements were developed that reflect the areas of potential controversy with high clinical impact. Faculty members were responsible for reviewing the literature to support or reject these statements. After a review and comprehensive discussion of the data, the HCV Council faculty voted on the nature of the evidence and the level of support for each statement.

resultsThe results of the detailed analysis with expert opinion are summarized in this article.

conclusionNumerous questions regarding optimal management of certain populations and clinical scenarios remain unanswered. The discussion in the article provides a summary of evidenced-based expert opinion that may help guide clinicians as additional information is developed.

Indexed as

Administration, OralAntiviral AgentsBenchmarkingConsensusDiffusion of InnovationDrug Administration ScheduleDrug Resistance, ViralDrug Therapy, CombinationGenotypeHepacivirusHepatitis C, ChronicHumansPhenotypeTime FactorsTreatment OutcomeViral LoadAntiviral Agentsdirect-acting antiviralgenotype 1a and 1bgenotype 2genotype 3hepatitis C virus

Identifiers

PMID26509462
PMCPMC5063106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.