Evidence map›Paper›PMID 26509414›Full record

ArticleJournal of biomedical optics2015

Monitoring photodynamic therapy with photoacoustic microscopy.

Peng Shao, David W Chapman, Ronald B Moore, Roger J Zemp

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Peng ShaoUniversity of Alberta, Department of Electrical & Computer Engineering, 9107-116 Street, Edmonton T6G 2V4, Canada.
David W ChapmanUniversity of Alberta, Department of Surgery and Oncology, 11560 University Avenue, Edmonton T6G 1Z2, Canada.
Ronald B MooreUniversity of Alberta, Department of Surgery and Oncology, 11560 University Avenue, Edmonton T6G 1Z2, Canada.
Roger J ZempUniversity of Alberta, Department of Electrical & Computer Engineering, 9107-116 Street, Edmonton T6G 2V4, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abstract. We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.

Indexed as

Drug MonitoringEquipment DesignEquipment Failure AnalysisFeasibility StudiesMicroscopy, AcousticPhotoacoustic TechniquesPhotochemotherapyReproducibility of ResultsSensitivity and SpecificityTreatment Outcome

Identifiers

PMID26509414
OpenAlexW2164456212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.