ArticlePloS one2015
Novel Trichoderma polysporum Strain for the Biocontrol of Pseudogymnoascus destructans, the Fungal Etiologic Agent of Bat White Nose Syndrome.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Culturable mycota from Karst caves in Yunnan Province, China.IMA fungus · 2026Article
- Mechanisms of volatile organic compounds from bat cave environments againstApplied and environmental microbiology · 2025Article
- Transcriptome Sequencing and Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Development of a multi-year white-nose syndrome mitigation strategy using antifungal volatile organic compounds.PloS one · 2022Article
- Genome-Wide Changes in Genetic Diversity in a Population ofG3 (Bethesda, Md.) · 2020Article
- Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018: Impact and Lessons Learned.Journal of clinical microbiology · 2020Article
- Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus).Scientific reports · 2019Article
- Trichoderma polysporum selectively inhibits white-nose syndrome fungal pathogen Pseudogymnoascus destructans amidst soil microbes.Microbiome · 2018Article
- Fungal endophytes inhabiting mountain-cultivated ginseng (Panax ginseng Meyer): Diversity and biocontrol activity against ginseng pathogens.Scientific reports · 2017Article
- Article
- Integrated Translatome and Proteome: Approach for Accurate Portraying of Widespread Multifunctional Aspects ofFrontiers in microbiology · 2017Review
- Microbial inhibitors of the fungus Pseudogymnoascus destructans, the causal agent of white-nose syndrome in bats.PloS one · 2017Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
White-nose syndrome (WNS), an emerging disease of hibernating bats, has rapidly spread across eastern North America killing millions of bats. Pseudogymnoascus destructans (Pd), the sole etiologic agent of WNS, is widespread and persistent in bat hibernacula. Control of Pd in the affected sites is urgently needed to break the transmission cycle while minimizing any adverse impact on the native organisms. We isolated a novel strain of Trichoderma polysporum (Tp) from one of the caves at the epicenter of WNS zoonotic. Detailed experimental studies revealed: (1) Tp WPM 39143 was highly adapted to grow at temperatures simulating the cave environment (6°C-15°C), (2) Tp WPM 39143 restricted Pd colony growth in dual culture challenges, (3) Tp WPM 39143 caused four logs reduction of Pd colony forming units and genome copies in autoclaved soil samples from one of the WNS affected caves, (4) Tp WPM 39143 extract showed specific fungicidal activity against Pd in disk diffusion assay, but not against closely related fungus P. pannorum (Pp), (5) Tp WPM 39143 extract retained inhibitory activity after exposure to high temperatures, light and proteinase K, and (6) Inhibitory metabolites in Tp WPM 39143 extract comprised of water-soluble, high polarity compounds. These results suggest that Tp WPM 39143 is a promising candidate for further evaluation as a biocontrol agent of Pd in WNS affected sites.
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