ArticleBiomacromolecules2015
Self-Healing and Thermoresponsive Dual-Cross-Linked Alginate Hydrogels Based on Supramolecular Inclusion Complexes.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Cyclodextrin-Grafted Polysaccharides as Sustainable Platforms for Biomedical and Environmental Applications.International journal of molecular sciences · 2026Review
- A review on β-cyclodextrin-based self-healable supramolecular systems: mechanisms and biomedical applications.RSC advances · 2026Review
- Article
- Fabrication andDesigned monomers and polymers · 2025Article
- Hydrogel-based cardiac patches for myocardial infarction therapy: Recent advances and challenges.Materials today. Bio · 2024Review
- Self-healing hydrogel as an injectable implant: translation in brain diseases.Journal of biomedical science · 2023Review
- A Supramolecular Hydrogel Based on Copolymers of Acrylic Acid and Maleic Anhydride Derivatives with Terpyridine Motifs.Polymers · 2022Article
- Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications.Polymers · 2021Review
- Preparation and Antibacterial Activity of Thermo-Responsive Nanohydrogels from Qiai Essential Oil and Pluronic F108.Molecules (Basel, Switzerland) · 2021Article
- Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels.Chemical reviews · 2021Review
- Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications.Polymers · 2020Review
- pH-Sensitive Folic Acid Conjugated Alginate Nanoparticle for Induction of Cancer-Specific Fluorescence Imaging.Pharmaceutics · 2020Article
- Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation.Biomacromolecules · 2020Article
- Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
- Efficient Grafting of Cyclodextrin to Alginate and Performance of the Hydrogel for Release of Model Drug.Scientific reports · 2019Article
- A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide⁻Metal Ion Coordination.Biomimetics (Basel, Switzerland) · 2019Article
- Dual-crosslinked homogeneous alginate microspheres for mesenchymal stem cell encapsulation.Journal of materials science. Materials in medicine · 2018Article
- Polysaccharide-Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Review
- Anticancer Therapeutic Alginate-Based Tissue Sealants for Lung Repair.ACS applied materials & interfaces · 2017Article
- Drug-Loadable Calcium Alginate Hydrogel System for Use in Oral Bone Tissue Repair.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
β-Cyclodextrin (β-CD), with a lipophilic inner cavity and hydrophilic outer surface, interacts with a large variety of nonpolar guest molecules to form noncovalent inclusion complexes. Conjugation of β-CD onto biomacromolecules can form physically cross-linked hydrogel networks upon mixing with a guest molecule. Herein, the development and characterization of self-healing, thermoresponsive hydrogels, based on host-guest inclusion complexes between alginate-graft-β-CD and Pluronic F108 (poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)), are described. The mechanics, flow characteristics, and thermal response were contingent on the polymer concentration and the host-guest molar ratio. Transient and reversible physical cross-linking between host and guest polymers governed self-assembly, allowing flow to occur under shear stress and facilitating complete recovery of the material's properties within a few seconds of unloading. The mechanical properties of the dual-cross-linked, multi-stimuli-responsive hydrogels were tuned as high as 30 kPa at body temperature and are advantageous for biomedical applications such as drug delivery and cell transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.