ArticleBioMed research international2015
Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies.International journal of biological sciences · 2025Review
- A novel approach to studying infective endocarditis: Ultrasound-guided wire injury and bacterial challenge in mice.PloS one · 2025Article
- Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index.Biomedicines · 2023Article
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- Models and Techniques to Study Aortic Valve CalcificationFrontiers in pharmacology · 2022Review
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- Article
- Calciprotein Particles: Balancing Mineral Homeostasis and Vascular Pathology.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Oxidized Low-Density Lipoprotein PromotesMaterials (Basel, Switzerland) · 2020Article
- Article
- Structural and crystal-chemical characteristics of the apatite deposits from human aortic walls.Interventional medicine & applied science · 2018Article
- CleAir Monitoring System for Particulate Matter: A Case in the Napoleonic Museum in Rome.Sensors (Basel, Switzerland) · 2017Article
- Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification.Heart (British Cardiac Society) · 2016Review
- Quantification of Calcium Amount in a New Experimental Model: A Comparison between Ultrasound and Computed Tomography.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent advances, mineralization site, its microarchitecture, and composition in calcific heart valve remain poorly understood. A multiscale investigation, using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectrometry (EDS), from micrometre up to nanometre, was conducted on human severely calcified aortic and mitral valves, to provide new insights into calcification process. Our aim was to evaluate the spatial relationship existing between bioapatite crystals, their local growing microenvironment, and the presence of a hierarchical architecture. Here we detected the presence of bioapatite crystals in two different mineralization sites that suggest the action of two different growth processes: a pathological crystallization process that occurs in biological niches and is ascribed to a purely physicochemical process and a matrix-mediated mineralized process in which the extracellular matrix acts as the template for a site-directed nanocrystals nucleation. Different shapes of bioapatite crystallization were observed at micrometer scale in each microenvironment but at the nanoscale level crystals appear to be made up by the same subunits.
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Registered trials
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