ArticleNeuroImage. Clinical2015
Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Reorganisation of Brain Hubs across Altered States of Consciousness.Scientific reports · 2020Trial
- Brain network dynamics in the wake-sleep transition reorganize according to task engagement.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans.Communications biology · 2024Article
- Article
- Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.Neurocritical care · 2022Article
- fMRI lag structure during waking up from early sleep stages.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.Neurocritical care · 2021Article
- Sedation Modulates Frontotemporal Predictive Coding Circuits and the Double Surprise Acceleration Effect.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study.Frontiers in neurology · 2020Article
- Consciousness-specific dynamic interactions of brain integration and functional diversity.Nature communications · 2019Article
- Propofol Anesthesia Increases Long-range Frontoparietal Corticocortical Interaction in the Oculomotor Circuit in Macaque Monkeys.Anesthesiology · 2019Article
- Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.British journal of anaesthesia · 2018Article
- Predicting seizure outcome of vagus nerve stimulation using MEG-based network topology.NeuroImage. Clinical · 2018Article
- Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states.Brain structure & function · 2017Article
- An unaware agenda: interictal consciousness impairments in epileptic patients.Neuroscience of consciousness · 2017Article
- Presurgical thalamocortical connectivity is associated with response to vagus nerve stimulation in children with intractable epilepsy.NeuroImage. Clinical · 2017Article
- Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics.Journal of the Royal Society, Interface · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.