ArticleNeuroImage. Clinical2015
Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Use of Functional MRI in Deep Brain Stimulation in Parkinson's Diseases: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease.Neurology · 2018Trial
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Medication versus globus pallidus internus deep brain stimulation in Parkinson's disease with deep learning video analysis of finger tapping.Scientific reports · 2025Observational
- Altered Cognitive Networks Connectivity in Parkinson's Disease During the Microlesion Period After Deep Brain Stimulation.CNS neuroscience & therapeutics · 2024Article
- Multimodal neuroimaging to characterize symptom-specific networks in movement disorders.NPJ Parkinson's disease · 2024Review
- Reorganization of motor network in patients with Parkinson's disease after deep brain stimulation.CNS neuroscience & therapeutics · 2024Article
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Cognitive aspects of motor control deteriorate while off treatment following subthalamic nucleus deep brain stimulation surgery in Parkinson's disease.Frontiers in neurology · 2024Article
- Subthalamic nucleus dynamics track microlesion effect in Parkinson's disease.Frontiers in cell and developmental biology · 2024Article
- Deep brain stimulation of the subthalamic nucleus in severe Parkinson's disease: relationships between dual-contact topographic setting and 1-year worsening of speech and gait.Acta neurochirurgica · 2023Observational
- Unsupervised physiological noise correction of functional magnetic resonance imaging data using phase and magnitude information (PREPAIR).Human brain mapping · 2023Article
- Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI.Frontiers in neurology · 2023Article
- Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson's Disease Rat Model.International journal of molecular sciences · 2022Article
- Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Walking exercise alters pedunculopontine nucleus connectivity in Parkinson's disease in a dose-dependent manner.Frontiers in neuroscience · 2022Article
- Effect of deep brain stimulation on brain network and white matter integrity in Parkinson's disease.CNS neuroscience & therapeutics · 2022Article
- Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Subthalamic and Pallidal Stimulations in Patients with Parkinson's Disease: Common and Dissociable Connections.Annals of neurology · 2021Article
- Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning.Nature communications · 2021Observational
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a "microlesion effect" (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with increased EC of functional connectivity in the brainstem. Changes in connectivity were quantitatively related to motor improvement, which further emphasizes the clinical importance of the functional integrity of the brainstem. Surprisingly, MLE and DBS were associated with anatomically different EC maps despite their similar clinical benefit on motor functions. The DBS solely caused an increase in connectivity of the left premotor region suggesting separate pathophysiological mechanisms of both interventions. While the DBS acts at the cortical level suggesting compensatory activation of less affected motor regions, the MLE affects more fundamental circuitry as the dysfunctional brainstem predominates in the beginning of PD. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.