Evidence map›Paper›PMID 26509005›Full record

ArticleClinical case reports2015

Transient neonatal diabetes due to a missense mutation (E227K) in the gene encoding the ATP-sensitive potassium channel (KCNJ11).

Luísa Martins, Rita Lourenço, Ana Lúcia Maia, Paula Maciel, Maria Isabel Monteiro, Lucinda Pacheco, João Anselmo, Rui César, Maria Fernanda Gomes

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Management of Neonatal Diabetes due to aCase reports in endocrinology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luísa MartinsPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Rita LourençoPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Ana Lúcia MaiaPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Paula MacielPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Maria Isabel MonteiroPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Lucinda PachecoPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
João AnselmoEndocrinology Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Rui CésarEndocrinology Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.
Maria Fernanda GomesPediatric Department, Hospital Divino Espírito Santo Ponta Delgada, Açores, 9500-317, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal diabetes is a monogenic form of diabetes. Herein, we report on a newborn presenting diabetic ketoacidosis at 17 days of life. A KCNJ11 mutation was identified. In such cases, insulin can be replaced by sulfonylurea with a successful metabolic control, as an example of how molecular diagnosis may influence the clinical management of the disorder.

Indexed as

InsulinKATP sensitive channelsKCNJ11 geneneonatal diabetes mellitussulfonylureas

Identifiers

PMID26509005
PMCPMC4614638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.