Evidence map›Paper›PMID 26509000›Full record

ArticleChemical science2015

Stereoselective synthesis of macrocyclic peptides via a dual olefin metathesis and ethenolysis approach.

Shane L Mangold, Robert H Grubbs

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 38 citations in OpenAlex.

  1. Antimicrobial and Adjuvant Potencies of Di-Antibiotics (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Design and Synthesis of HelicalMolecules (Basel, Switzerland) · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Shane L MangoldArnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, USA..
Robert H GrubbsArnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, USA..
Division of Chemistry · USPasadena City College · US

Funding

REAGENTS FOR ORGANIC SYNTHESIS BASED ON TRANSITION METALR01GM031332 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRUBBS, ROBERT HOWARD · 1985 to 2016
$6.1M
400 MHz Nuclear Magnetic Resonance SpectrometerS10RR027690 · NCRR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI VANDERVELDE, DAVID G · 2010 to 2010
$315k
NCRR NIH HHS S10 RR027690NIGMS NIH HHS R01 GM031332
6 · The paper itself

Abstract

Macrocyclic compounds occupy an important chemical space between small molecules and biologics and are prevalent in many natural products and pharmaceuticals. The growing interest in macrocycles has been fueled, in part, by the design of novel synthetic methods to these compounds. One appealing strategy is ring-closing metathesis (RCM) that seeks to construct macrocycles from acyclic diene precursors using defined transition-metal alkylidene catalysts. Despite its broad utility, RCM generally gives rise to a mixture of

Identifiers

PMID26509000
PMCPMC4618480
OpenAlexW2107537090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.