Evidence map›Paper›PMID 26508995›Full record

ArticleChemical science2015

Enantioselective reductive multicomponent coupling reactions between isatins and aldehydes.

Matthew A Horwitz, Naoya Tanaka, Takuya Yokosaka, Daisuke Uraguchi, Jeffrey S Johnson, Takashi Ooi

Abstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Recent Developments in the [1,2]-Phospha-Brook Rearrangement Reaction.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Phosphine Organocatalysis.Chemical reviews · 2018
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew A HorwitzDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Naoya TanakaInstitute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho D2-1, Chikusa, Nagoya 464-8602, Japan.
Takuya YokosakaDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Daisuke UraguchiInstitute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho D2-1, Chikusa, Nagoya 464-8602, Japan.
Jeffrey S JohnsonDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Takashi OoiInstitute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho D2-1, Chikusa, Nagoya 464-8602, Japan ; CREST, Japan Science and Technology Agency (JST), Nagoya University, Nagoya 464-8603, Japan.

Funding

New Dynamic Processes for the Preparation of Biologically Active Small MoleculesR01GM103855 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHNSON, JEFFREY S · 2013 to 2015
$554k
NIGMS NIH HHS R01 GM103855
6 · The paper itself

Abstract

A metal-free stereoselective reductive coupling reaction between isatins and aldehydes is reported. The reaction relies on commercial diethyl phosphite (∼€70 kg

Identifiers

PMID26508995
PMCPMC4618493

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.