ArticleClinical epidemiology2015
Tuberculosis case finding in first-degree relative contacts not living with index tuberculosis cases in Kampala, Uganda.
Article in Clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- A proteome-wide atlas of humoral immunity toFrontiers in immunology · 2026Article
- Implementing active surveillance for tuberculosis: The experiences of healthcare workers at four sites in two provinces in South Africa.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022Article
- Scaling up investigation and treatment of household contacts of tuberculosis patients in Brazil: a cost-effectiveness and budget impact analysis.Lancet regional health. Americas · 2022Article
- Article
- Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar.Tropical medicine and infectious disease · 2019Article
- IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure.Nature medicine · 2019Article
- Article
- Digital CXR with computer aided diagnosis versus symptom screen to define presumptive tuberculosis among household contacts and impact on tuberculosis diagnosis.BMC infectious diseases · 2017Article
- Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.PloS one · 2017Article
- The Yield of Community-Based "Retrospective" Tuberculosis Contact Investigation in a High Burden Setting in Ethiopia.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo assess the prevalence of pulmonary tuberculosis among first-degree relative (FDR) contacts not living with tuberculosis (TB) cases.
methodsA cross-sectional analysis of household contacts living with an index TB case and FDR contacts living outside of households in Kampala, Uganda, is presented.
resultsA total of 177 contacts (52 FDRs and 125 index household contacts) of 31 TB cases were examined. Compared with index household contacts, FDR contacts were older, more likely to be TB symptomatic (50% vs 33%), had a higher percentage of abnormal chest X-rays (19% vs 11%), sputum smear positive (15% vs 5%), and many similar epidemiologic risk factors, including HIV infection (13% vs 10%). Contact groups had similar pulmonary tuberculosis prevalence: 9.6% in FDR vs 10.4% in index household contacts and similar Mycobacterium tuberculosis infection: 62% in FDR vs 61% in index households.
conclusionTB is common among FDR contacts. High TB prevalence justifies targeting FDRs during household contact investigations. Combining TB active-case finding among FDR contacts with household contact investigation in low-income setting is feasible. This should be part of national TB control program strategies for increasing TB case-detection rates and reducing community TB transmission and death.
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