Evidence map›Paper›PMID 26508745›Full record

ArticleJournal of the American Heart Association2015

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury.

Daniela Lobenwein, Can Tepeköylü, Radoslaw Kozaryn, Elisabeth J Pechriggl, Mario Bitsche, Michael Graber, Helga Fritsch, Severin Semsroth, Nadia Stefanova, Patrick Paulus and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models.Journal of neuropathology and experimental neurology · 2021
    Pooled it
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  12. Physical Considerations for In Vitro ESWT Research Design.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Daniela LobenweinUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Can TepeköylüUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Radoslaw KozarynUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Elisabeth J PechrigglUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.) Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria (E.J.P., M.B., H.F.).
Mario BitscheDivision of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria (E.J.P., M.B., H.F.).
Michael GraberUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Helga FritschDivision of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Innsbruck, Austria (E.J.P., M.B., H.F.).
Severin SemsrothUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Nadia StefanovaDivision of Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria (N.S.).
Patrick PaulusDepartment of Anesthesiology and Operative Intensive Care Medicine, Kepler University Hospital Linz, Linz, Austria (P.P.).
Martin CzernyDepartment for Cardiovascular Surgery, University Hospital Freiburg, Freiburg, Germany (M.C.).
Michael GrimmUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Johannes HolfeldUniversity Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria (D.L., C.T., R.K., E.J.P., M.G., S.S., M.G., J.H.).
Innsbruck Medical University · ATUniversity Hospital Innsbruck · ATKepler Universitätsklinikum · ATUniversity Medical Center Freiburg · DE

Funding

Austrian Science Fund FWF F 4414Austrian Science Fund FWF P 25161
6 · The paper itself

Abstract

backgroundParaplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in ischemic tissue by modulation of early inflammatory response via Toll-like receptor (TLR) 3 signaling. In preclinical and clinical studies, shock wave treatment had a favorable effect on ischemic myocardium. We hypothesized that shock wave treatment also may have a beneficial effect on spinal cord ischemia. METHODS AND

resultsA spinal cord ischemia model in mice and spinal slice cultures ex vivo were performed. Treatment groups received immediate shock wave therapy, which resulted in decreased neuronal degeneration and improved motor function. In spinal slice cultures, the activation of TLR3 could be observed. Shock wave effects were abolished in spinal slice cultures from TLR3(-/-) mice, whereas the effect was still present in TLR4(-/-) mice. TLR4 protein was found to be downregulated parallel to TLR3 signaling. Shock wave-treated animals showed significantly better functional outcome and survival. The protective effect on neurons could be reproduced in human spinal slices.

conclusionsShock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 downregulation. Consequently, it represents a promising treatment option for the devastating complication of spinal cord ischemia after aortic repair.

Indexed as

High-Energy Shock WavesNerve DegenerationAnimalsCadaverDisease Models, AnimalHumansIn Vitro TechniquesMaleMice, Inbred C57BLMice, KnockoutMotor ActivityNeovascularization, PhysiologicRegional Blood FlowSignal TransductionSpinal CordSpinal Cord InjuriesTLR3 protein, mouseTlr4 protein, mouseToll-Like Receptor 3Toll-Like Receptor 4neuronal degenerationshock wave therapyspinal cord ischemiaToll‐like receptors

Identifiers

PMID26508745
PMCPMC4845137
OpenAlexW2177398563

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.