Evidence map›Paper›PMID 26508743›Full record

SynthesisJournal of the American Heart Association2015

Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Fenglei Wang, Jusheng Zheng, Bo Yang, Jiajing Jiang, Yuanqing Fu, Duo Li

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02905448 (Effects of an ad Libitum Consumed Low-fat Plant-based Diet Supplemented With Plant-based Meal Replacements on Variety of Risk Factors for Chronic Non-communicable Diseases), which is not on this map. Cited by 148 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02905448 nacompletednot on this mapstarted 2016, after this paper: background citation

Effects of an ad Libitum Consumed Low-fat Plant-based Diet Supplemented With Plant-based Meal Replacements on Variety of Risk Factors for Chronic Non-communicable Diseases

TypeinterventionalSponsorBarbara Jakše s.p.Ran2016 to 2017Enrolled36ConditionsHyperlipidemia, Metabolic Syndrome XArmsLow fat plant-based nutrition
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  9. Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Fenglei WangDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).
Jusheng ZhengDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).
Bo YangDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).
Jiajing JiangDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).
Yuanqing FuDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).
Duo LiDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou, China (F.W., J.Z., B.Y., J.J., Y.F., D.L.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVegetarian diets exclude all animal flesh and are being widely adopted by an increasing number of people; however, effects on blood lipid concentrations remain unclear. This meta-analysis aimed to quantitatively assess the overall effects of vegetarian diets on blood lipids. METHODS AND

resultsWe searched PubMed, Scopus, Embase, ISI Web of Knowledge, and the Cochrane Library through March 2015. Studies were included if they described the effectiveness of vegetarian diets on blood lipids (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride). Weighted mean effect sizes were calculated for net changes by using a random-effects model. We performed subgroup and univariate meta-regression analyses to explore sources of heterogeneity. Eleven trials were included in the meta-analysis. Vegetarian diets significantly lowered blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, and the pooled estimated changes were -0.36 mmol/L (95% CI -0.55 to -0.17; P<0.001), -0.34 mmol/L (95% CI -0.57 to -0.11; P<0.001), -0.10 mmol/L (95% CI -0.14 to -0.06; P<0.001), and -0.30 mmol/L (95% CI -0.50 to -0.10; P=0.04), respectively. Vegetarian diets did not significantly affect blood triglyceride concentrations, with a pooled estimated mean difference of 0.04 mmol/L (95% CI -0.05 to 0.13; P=0.40).

conclusionsThis systematic review and meta-analysis provides evidence that vegetarian diets effectively lower blood concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol. Such diets could be a useful nonpharmaceutical means of managing dyslipidemia, especially hypercholesterolemia.

Indexed as

Diet, VegetarianVegetariansBiomarkersDown-RegulationDyslipidemiasHumansLipidsBiomarkersLipidscholesteroldietlipoprotein lipidstriglyceridevegetarian

Identifiers

PMID26508743
PMCPMC4845138

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.