ArticlePhysiological reports2015
Arterial to end-tidal Pco2 difference during exercise in normoxia and severe acute hypoxia: importance of blood temperature correction.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Exercise impairment in patients with pectus excavatum? A scoping review of evidence and role of arterial content change during effort.Physiological reports · 2026Article
- Exercise Increases the Sensitivity of Cerebral Glucose Metabolism to Intranasal Insulin in Young, Healthy Adults.Journal of neurochemistry · 2026Article
- Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- End-Tidal Carbon Dioxide Pressure Measurement after Prolonged Inspiratory Time Gives a Good Estimation of the Arterial Carbon Dioxide Pressure in Mechanically Ventilated Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Continuous reduction in cerebral oxygenation during endurance exercise in patients with pulmonary arterial hypertension.Physiological reports · 2020Article
- Progress Update and Challenges onFrontiers in physiology · 2020Review
- Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- What limits performance during whole-body incremental exercise to exhaustion in humans?The Journal of physiology · 2015Article
- Limitations to oxygen transport and utilization during sprint exercise in humans: evidence for a functional reserve in muscle O2 diffusing capacity.The Journal of physiology · 2015Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Negative arterial to end-tidal pco2 differences ((a-ET)pco2) have been reported in normoxia. To determine the influence of blood temperature on (a-ET)pco2, 11 volunteers (21 ± 2 years) performed incremental exercise to exhaustion in normoxia (Nx, Pio2: 143 mmHg) and hypoxia (Hyp, Pio2: 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with end-tidal pco2 (PE tco2). After accounting for blood temperature, the (a-ET) pco2 was reduced (in absolute values) from -4.2 ± 1.6 to -1.1 ± 1.5 mmHg in normoxia and from -1.7 ± 1.6 to 0.9 ± 0.9 mmHg in hypoxia (both P < 0.05). The temperature corrected (a-ET)pco2 was linearly related with absolute and relative exercise intensity, VO2, VCO2, and respiratory rate (RR) in normoxia and hypoxia (R(2): 0.52-0.59). Exercise CO2 production and PE tco2 values were lower in hypoxia than normoxia, likely explaining the greater (less negative) (a-ET)pco2 difference in hypoxia than normoxia (P < 0.05). At near-maximal exercise intensity the (a-ET)pco2 lies close to 0 mmHg, that is, the mean Paco2 and the mean PE tco2 are similar. The mean exercise (a-ET)pco2 difference is closely related to the mean A-aDO2 difference (r = 0.90, P < 0.001), as would be expected if similar mechanisms perturb the gas exchange of O2 and CO2 during exercise. In summary, most of the negative (a-ET)pco2 values observed in previous studies are due to lack of correction of Paco2 for blood temperature. The absolute magnitude of the (a-ET)pco2 difference is lower during exercise in hypoxia than normoxia.
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