ArticlePediatric nephrology (Berlin, Germany)2016
Hypertension in late adolescence and cardiovascular mortality in midlife: a cohort study of 2.3 million 16- to 19-year-old examinees.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Australian Guideline for the Identification and Management of Hypertension in Children and Adolescents.Journal of paediatrics and child health · 2026Article
- Untargeted metabolomics identifies altered metabolome contributing to hypertension in late adolescents.Journal of translational medicine · 2026Article
- Article
- The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods.American journal of epidemiology · 2024Article
- Pediatric Blood Pressure and Cardiovascular Health in Adulthood.Current hypertension reports · 2024Review
- Associations Between Prematurity, Birthweight, and Adolescence Blood Pressure in a Nationwide Cohort.Kidney international reports · 2024Article
- Associations of adolescent obesity with hypertension, diabetes mellitus and polycystic ovaries in Arabs and Jews in Israel-a nationwide study.Frontiers in public health · 2024Article
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- The Role of Triglyceride-Glucose Index in the Prediction of the Development of Hypertension - Findings from a Community Cohort in Singapore.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Prevention of atherosclerosis from childhood.Nature reviews. Cardiology · 2022Review
- Timing of procedural interventions in childhood renovascular hypertension.Pediatric nephrology (Berlin, Germany) · 2021Article
- Hypertension and childhood stroke.Pediatric nephrology (Berlin, Germany) · 2021Review
- ANTHROPOMETRIC MEASUREMENTS, DIETARY HABITS, SERUM LIPID AND GLUCOSE LEVELS IN RELATION TO HIGH BLOOD PRESSURE AMONG ADOLESCENT BOYS AND GIRLS IN CROATIA.Acta clinica Croatica · 2020Article
- Haemodynamics of Hypertension in Children.Current hypertension reports · 2020Review
- Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Association of Adolescent Hypertension With Future End-stage Renal Disease.JAMA internal medicine · 2019Article
- Assessment of risk factors for coronary artery disease in military personnel: A study from Iran.Journal of family medicine and primary care · 2019Article
- Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.Hypertension (Dallas, Tex. : 1979) · 2018Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of early hypertension on midlife cardiovascular (CV) mortality remains controversial. We assessed the association of established hypertension in late adolescence with subsequent CV mortality.
methodsOf 2,298,130 Israeli adolescents (60% males; age 17.4 ± 0.3 years) who underwent a compulsory medical examination prior to military service between 1967 and 2010, 8720 teenagers (0.4%) were formally diagnosed with persistent hypertension. Using Cox proportional hazards modeling, we compared the hypertensive group to the large normotensive group with regard to time to event analysis of midlife mortality due to cerebrovascular accidents (CVA), coronary heart disease (CHD), sudden death (SD) and their summation as cardiovascular disease (CVD).
resultsDuring 45,729,521 person-years of follow-up, we identified 2918 CV deaths-2879 and 39 among the 2,289,410 normotensive and 8720 hypertensive adolescents, respectively. Hypertension at a young age was associated with a threefold elevation of stroke mortality compared to normotension when adjusted for sex, age at examination, birth year, country of origin, socioeconomic status, education, body mass index (BMI) and height [hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.76-5.54; p < 0.001]. There was no significant association of hypertension with CHD mortality or SD. An increased risk for overall CVD mortality among hypertensive youngsters (HR 1.51; 95 % CI 1.10-2.07) was attenuated after adjusting for BMI and other covariates (HR 1.24; 95% CI 0.90-1.72).
conclusionsEstablished hypertension at a young age was independently associated with elevated stroke mortality in midlife. This finding warrants confirmatory large-scale long-term follow-up studies to address the distant effects of adolescent hypertension.
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