Evidence map›Paper›PMID 26508368›Full record

ReviewProteomics2016

Capillary zone electrophoresis for bottom-up analysis of complex proteomes.

Liangliang Sun, Guijie Zhu, Xiaojing Yan, Zhenbin Zhang, Roza Wojcik, Matthew M Champion, Norman J Dovichi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Quenching Trypsin Is Unnecessary in Filter-Based Bottom-Up Proteomics.Journal of the American Society for Mass Spectrometry · 2024
    Article
  5. Peptidomics and Capillary Electrophoresis.Advances in experimental medicine and biology · 2021
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liangliang SunDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Guijie ZhuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Xiaojing YanDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Zhenbin ZhangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Roza WojcikDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Matthew M ChampionDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
Norman J DovichiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.

Funding

Technology for single cell proteomics and its application to the analysis of single Xenopus blastomeresR01GM096767 · NIGMS · UNIVERSITY OF NOTRE DAME · PI DOVICHI, NORMAN J · 2011 to 2019
$2.5M
NIGMS NIH HHS R01 GM096767NIGMS NIH HHS R01GM096767
6 · The paper itself

Abstract

Capillary zone electrophoresis (CZE) is emerging as a useful tool in proteomic analysis. Interest arises from dramatic improvements in performance that result from improvements in the background electrolyte used for the separation, the incorporation of advanced sample injection methods, the development of robust and sensitive electrospray interfaces, and the coupling with Orbitrap mass spectrometers with high resolution and sensitivity. The combination of these technologies produces performance that is rapidly approaching the performance of UPLC-based methods for microgram samples and exceeds the performance of UPLC-based methods for mid- to low nanogram samples. These systems now produce over 10 000 peptide IDs in a single 100-min analysis of the HeLa proteome.

Indexed as

Electrophoresis, CapillaryHumansProteomeProteomicsQuality ImprovementSpectrometry, Mass, Electrospray IonizationProteomeBottom-up proteomicsCapillary electrophoresisCell biologyElectrokinetically pumped nanosprayTechnology

Identifiers

PMID26508368
PMCPMC4771184

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.