ArticleNature communications2015
Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Cephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).Journal of insect science (Online) · 2024Article
- Finishing the egg.Genetics · 2024Article
- A transitory signaling center controls timing of primordial germ cell differentiation.Developmental cell · 2021Article
- Receptor Tyrosine Kinases in Development: Insights fromInternational journal of molecular sciences · 2019Review
- TheBiology open · 2019Article
- Article
- The trigger (and the restriction) of Torso RTK activation.Open biology · 2018Review
- Holes in the Plasma Membrane Mimic Torso-Like Perforin in Torso Tyrosine Kinase Receptor Activation in theGenetics · 2018Article
- Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway inGenetics · 2018Article
- Genome-Wide Screen for New Components of theG3 (Bethesda, Md.) · 2018Article
- Comparative RNA-sequencing analysis of ER-based HSP90 functions and signal pathways in Tribolium castaneum.Cell stress & chaperones · 2018Article
- Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.Developmental cell · 2017Article
- Maternal Torso-Like Coordinates Tissue Folding DuringGenetics · 2017Article
- Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins inGenetics · 2017Article
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.Development (Cambridge, England) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patterning of the Drosophila embryonic termini is achieved by localized activation of the Torso receptor by the growth factor Trunk. Governing this event is the perforin-like protein Torso-like, which is localized to the extracellular space at the embryo poles and has long been proposed to control localized proteolytic activation of Trunk. However, a protease involved in terminal patterning remains to be identified, and the role of Torso-like remains unknown. Here we find that Trunk is cleaved intracellularly by Furin proteases. We further show that Trunk is secreted, and that levels of extracellular Trunk are greatly reduced in torso-like null mutants. On the basis of these and previous findings, we suggest that Torso-like functions to mediate secretion of Trunk, thus providing the mechanism for spatially restricted activation of Torso. Our data represent an alternative mechanism for the spatial control of receptor signalling, and define a different role for perforin-like proteins in eukaryotes.
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