ArticleNature communications2015
Mussel adhesion is dictated by time-regulated secretion and molecular conformation of mussel adhesive proteins.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
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- A robust adhesive microneedle for oral infections therapy via synergistic antibacterial and neutrophil-macrophage axis immunomodulation.Science advances · 2026Article
- Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Bioinspired bioadhesion: translating nature's adhesive strategies into regenerative medicine.Med-X · 2026Review
- Harnessing marine-derived materials for therapeutics innovations: Advances in biomaterials from the ocean.Materials today. Bio · 2025Review
- De novo transcriptome analysis of Perna perna L. (Bivalve) with functional and metabolic pathway analysis.Scientific data · 2025Article
- Perceiving and Countering Marine Biofouling: Structure, Forces, and Processes at Surfaces in Sea Water Across the Length Scales.Langmuir : the ACS journal of surfaces and colloids · 2025Review
- Protein-based materials: Applications, modification and molecular design.Biodesign research · 2025Review
- Pharmacological effects and application prospects of mussel adhesive proteins.Frontiers in pharmacology · 2025Review
- Molecular Mechanism of Oil-Infused Silicone Preventing Mussel Biofouling.Research (Washington, D.C.) · 2025Article
- Article
- Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D.International journal of molecular sciences · 2024Review
- Molecular Crowding: The History and Development of a Scientific Paradigm.Chemical reviews · 2024Review
- Genetic Diversity, Population Structure, and Environmental Adaptation Signatures of Chinese Coastal Hard-Shell MusselInternational journal of molecular sciences · 2023Article
- Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy.Nature communications · 2023Article
- Enzymatic polymerization of enantiomericNature communications · 2023Article
- Applications of synthetic biology in medical and pharmaceutical fields.Signal transduction and targeted therapy · 2023Review
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding.Materials today. Bio · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the currently known design principles of mussel adhesion, here we elucidate the precise time-regulated secretion of P. viridis mussel adhesive proteins. The vanguard 3,4-dihydroxy-L-phenylalanine (Dopa)-rich protein Pvfp-5 acts as an adhesive primer, overcoming repulsive hydration forces by displacing surface-bound water and generating strong surface adhesion. Using homology modelling and molecular dynamics simulations, we find that all mussel adhesive proteins are largely unordered, with Pvfp-5 adopting a disordered structure and elongated conformation whereby all Dopa residues reside on the protein surface. Time-regulated secretion and structural disorder of mussel adhesive proteins appear essential for optimizing extended nonspecific surface interactions and byssus' assembly. Our findings reveal molecular-scale principles to help the development of wet-resistant adhesives.
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