SynthesisInternational journal of colorectal disease2016
Prediction of anastomotic leak in colorectal cancer surgery based on a new prognostic index PROCOLE (prognostic colorectal leakage) developed from the meta-analysis of observational studies of risk factors.
Synthesis in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05411783 (Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinical Trial. LOTHVEIN Study
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Score prediction of anastomotic leak in colorectal surgery: a systematic review.Surgical endoscopy · 2024Pooled it
- Ghost Ileostomy Versus Loop Ileostomy Following Oncologic Resection for Rectal Cancer: A Systematic Review and Meta-Analysis.Surgical innovation · 2023Pooled it
- Systematic review of preoperative and intraoperative colorectal Anastomotic Leak Prediction Scores (ALPS).BMJ open · 2023Pooled it
- Preoperative risk factors associated with anastomotic leakage after colectomy for colorectal cancer: a systematic review and meta-analysis.Revista do Colegio Brasileiro de Cirurgioes · 2022Pooled it
- Obesity and anastomotic leak rates in colorectal cancer: a meta-analysis.International journal of colorectal disease · 2021Pooled it
- A Systematic Review and Meta-Analysis of Prediction Scores for Anastomotic Leak Following Colorectal Surgery.Maedica · 2026Review
- Development of a Clinical Framework-Anastomotic Leakage Prediction Score (CF-ALPS) After Colorectal Surgery.Diagnostics (Basel, Switzerland) · 2025Article
- Risk Factors for Sigmoid Colonic Anastomosis: A Comparative and Cross-Sectional Analysis.Therapeutics and clinical risk management · 2025Article
- Machine learning-based preoperative analytics for the prediction of anastomotic leakage in colorectal surgery: a swiss pilot study.Surgical endoscopy · 2024Article
- Impact of COVID-19 infection during the postoperative period in patients who underwent gastrointestinal surgery: a retrospective study.Annals of surgical treatment and research · 2024Article
- Differential Performance of Machine Learning Models in Prediction of Procedure-Specific Outcomes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- A Prediction Model for Severe Complications after Elective Colorectal Cancer Surgery in Patients of 70 Years and Older.Cancers · 2021Article
- Colorectal anastomosis dehiscence: a call for more detailed morphological classification.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2021Article
- Assessing abdominal aortic calcifications before performing colocolic or colorectal anastomoses: A case-control study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Anastomotic bleeding following ileocolic end-to-side anastomosis using a circular stapler: incidence and risk factors.Surgery today · 2020Article
- Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery.Scientific reports · 2020Article
- Development of a Risk Score to Predict Anastomotic Leak After Left-Sided Colectomy: Which Patients Warrant Diversion?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Reconstructive Surgery for Intestinal Failure.Visceral medicine · 2019Review
- Modified Colon Leakage Score to Predict Anastomotic Leakage in Patients Who Underwent Left-Sided Colorectal Surgery.Journal of clinical medicine · 2019Article
- Intraoperative air leak test reduces the rate of postoperative anastomotic leak: analysis of 777 laparoscopic left-sided colon resections.Surgical endoscopy · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo obtain a prognostic index, which has been named PROCOLE (prognostic colorectal leakage), it can predict the risk that a certain individual may suffer anastomotic leakage.
methodsThe methodology consists of a systematic review to identify potential risk factors for anastomotic leakage and a meta-analysis of studies of each of these factors. In the meta-analysis, the prognostic index integrates factors that are statistically significant, which are weighted according to the estimated value of the effect size. The prognostic index was validated using retrospectively collected data from patients who underwent colorectal cancer surgery anastomosis at our institution.
resultsThe mean and standard deviation of the PROCOLE prognostic index in patients with anastomotic leakage is 1.9 ± 6.13, whereas in controls, it is 3.63 ± 2.1. The predictive ability of the PROCOLE, assessed by calculating the area under the curve (AUC) of the receiver operating characteristic (ROC), results in an AUC of 0.82 with a 95% confidence interval (CI) (0.75, 0.89) of the AUC, and it can be considered a good prognostic indicator.
conclusionsThe PROCOLE prognostic index predicts the risk of a certain individual developing anastomotic leakage after colorectal cancer surgery. Specifically, the PROCOLE prognostic index establishes a discrimination value threshold of 4.83 for recommending the implementation of a protective stoma. We have developed free software with a simple interface that only requires the selection of risk factors to obtain the PROCOLE value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.