Evidence map›Paper›PMID 26507871›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2016

Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth.

David M Haas, Dongbing Lai, Sunita Sharma, Jenny Then, Alvin Kho, David A Flockhart, Kelan Tantisira, Tatiana Foroud

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Translational Systems Pharmacology Studies in Pregnant Women.CPT: pharmacometrics & systems pharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

David M HaasIndiana University School of Medicine, Indianapolis, IN, USA dahaas@iupui.edu.
Dongbing LaiIndiana University School of Medicine, Indianapolis, IN, USA.
Sunita SharmaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Jenny ThenIndiana University School of Medicine, Indianapolis, IN, USA.
Alvin KhoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
David A FlockhartIndiana University School of Medicine, Indianapolis, IN, USA.
Kelan TantisiraChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Tatiana ForoudIndiana University School of Medicine, Indianapolis, IN, USA.
Indiana University School of MedicineHarvard University · USBrigham and Women's Hospital · USIndiana University – Purdue University Indianapolis · US

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
Indiana PREGMEDU10HD063094 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$4.2M
INTEGRATIVE PHARMACOGENOMICS OF LEUKOTRIENE INHIBITION IN ASTHMAR01HL092197 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2009 to 2013
$3.6M
INTRAUTERINE SMOKE EXPOSURE AND ASTHMA: GENOMIC ORIGINSR01HL097144 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KOBZIK, LESTER, WEISS, SCOTT T · 2009 to 2013
$2.9M
A Developmental Basis for Chronic Obstructive Lung DiseaseK25HL091124 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KHO, ALVIN THONG-JUAK · 2008 to 2012
$743k
INTEGRATIVE GENOMICS AND THE FETAL ORIGINS OF IMPAIRED LUNG FUNCTIONK08HL096833 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHARMA, SUNITA · 2010 to 2013
$547k
Pharmacogenetics of antenatal corticosteroids to improve neonatal outcomesK23HD055305 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2008 to 2011
$539k
NHLBI NIH HHS K08 HL096833NHLBI NIH HHS K08HL096833NHLBI NIH HHS K25 HL091124NHLBI NIH HHS R01 HL092197NHLBI NIH HHS R01HL092197NHLBI NIH HHS R01 HL097144NHLBI NIH HHS R01HL097144NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01HL65899NICHD NIH HHS 5K23HD055305NICHD NIH HHS 5U01HD063094NICHD NIH HHS K23 HD055305NICHD NIH HHS U10 HD063094
6 · The paper itself

Abstract

objectiveTo test several key glucocorticoid genes that are enhanced in lung development for associations with respiratory distress syndrome (RDS) after antenatal corticosteroid use.

methodsA prospective cohort of women received betamethasone to accelerate fetal lung maturity for threatened preterm delivery. DNA was obtained from mothers and newborns. Neonatal RDS was the primary outcome. Genotyping for single-nucleotide polymorphisms (SNPs) in 68 glucocorticoid genes found to be differentially expressed during lung development was performed. Multivariable analysis tested for associations of SNPs in the candidate genes with RDS.

resultsGenotypic results for 867 SNPs in 96 mothers and 73 babies were included. Thirty-nine (53.4%) babies developed RDS. Maternal SNPs in the centromeric protein E (CENPE), GLRX, CD9, and AURKA genes provided evidence of association with RDS (P < .01). In newborns, SNPs in COL4A3, BHLHE40, and SRGN provided evidence of association with RDS (P < .01).

conclusionSingle-nucleotide polymorphisms in several glucocorticoid responsive genes suggest association with neonatal RDS after antenatal corticosteroid use.

Indexed as

AdultBetamethasoneCohort StudiesFemaleGlucocorticoidsHumansInfant, NewbornPolymorphism, Single NucleotidePregnancyPremature BirthProspective StudiesRespiratory Distress Syndrome, NewbornSignal TransductionYoung AdultBetamethasoneGlucocorticoidsantenatal corticosteroidpharmacogeneticspregnancypreterm labor

Identifiers

PMID26507871
PMCPMC5933159
OpenAlexW2336284910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.