ArticleScientific reports2015
The commensal infant gut meta-mobilome as a potential reservoir for persistent multidrug resistance integrons.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Temporal dynamics & determinants of antibiotic resistance gene profiles in the infant gut during the first year of life.The Indian journal of medical research · 2025Article
- Dynamics of the digestive acquisition of bacterial carriage and integron presence by French preterm newborns according to maternal colonization: The DAIR3N multicentric study.Frontiers in microbiology · 2023Article
- Metagenomics analysis of the neonatal intestinal resistome.Frontiers in pediatrics · 2023Article
- Activation of class 1 integron integrase is promoted in the intestinal environment.PLoS genetics · 2022Article
- Incompatibility Group I1 (IncI1) Plasmids: Their Genetics, Biology, and Public Health Relevance.Microbiology and molecular biology reviews : MMBR · 2021Review
- Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission.Experimental & molecular medicine · 2021Review
- Grand Challenges in Understanding Gut Microbes.Frontiers in microbiology · 2021Article
- Experimental support for multidrug resistance transfer potential in the preterm infant gut microbiota.Pediatric research · 2020Observational
- Potential Elimination of Human Gut Resistome by Exploiting the Benefits of Functional Foods.Frontiers in microbiology · 2020Review
- Perinatal risk factors for fecal antibiotic resistance gene patterns in pregnant women and their infants.PloS one · 2020Article
- Human Milk Microbiota: Transferring the Antibiotic Resistome to Infants.Indian journal of microbiology · 2019Review
- Microbiome as a tool and a target in the effort to address antimicrobial resistance.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evaluating biological plausibility in supporting evidence for action through systematic reviews in public health.Public health · 2018Article
- Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.Nature communications · 2018Article
- Antibiotic Resistance Acquisition in the First Week of Life.Frontiers in microbiology · 2018Article
- Early microbiota, antibiotics and health.Cellular and molecular life sciences : CMLS · 2018Review
- Association of the gut microbiota mobilome with hospital location and birth weight in preterm infants.Pediatric research · 2017Article
- The Threat of Antimicrobial Resistance on the Human Microbiome.Microbial ecology · 2017Review
- Potential Effects of Horizontal Gene Exchange in the Human Gut.Frontiers in immunology · 2017Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the accumulating knowledge on the development and establishment of the gut microbiota, its role as a reservoir for multidrug resistance is not well understood. This study investigated the prevalence and persistence patterns of an integrase gene (int1), used as a proxy for integrons (which often carry multiple antimicrobial resistance genes), in the fecal microbiota of 147 mothers and their children sampled longitudinally from birth to 2 years. The study showed the int1 gene was detected in 15% of the study population, and apparently more persistent than the microbial community structure itself. We found int1 to be persistent throughout the first two years of life, as well as between mothers and their 2-year-old children. Metagenome sequencing revealed integrons in the gut meta-mobilome that were associated with plasmids and multidrug resistance. In conclusion, the persistent nature of integrons in the infant gut microbiota makes it a potential reservoir of mobile multidrug resistance.
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