ArticleEuropean child & adolescent psychiatry2016
The influence of comorbid oppositional defiant disorder on white matter microstructure in attention-deficit/hyperactivity disorder.
Article in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Neurological and biological correlations of ODD with ADHD in children and adolescents: a systematic review.BMC psychology · 2026Pooled it
- Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.BMC psychiatry · 2025Article
- Article
- Article
- Attention-deficit/hyperactivity disorder and white matter microstructure: the importance of dimensional analyses and sex differences.JCPP advances · 2022Article
- The potential shared brain functional alterations between adults with ADHD and children with ADHD co-occurred with disruptive behaviors.Child and adolescent psychiatry and mental health · 2022Article
- Association of self-regulation with white matter correlates in boys with and without autism spectrum disorder.Scientific reports · 2020Article
- Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Comorbidity prevalence and treatment outcome in children and adolescents with ADHD.European child & adolescent psychiatry · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) are highly comorbid disorders. ADHD has been associated with altered white matter (WM) microstructure, though the literature is inconsistent, which may be due to differences in the in- or exclusion of participants with comorbid ODD. WM abnormalities in ODD are still poorly understood, and it is unclear whether comorbid ODD in ADHD may have confounded the current ADHD literature. Diffusion Tensor Imaging (DTI) was used to compare fractional anisotropy (FA) and mean diffusivity (MD) between ADHD patients with (n = 42) and without (n = 117) comorbid ODD. All participants were between 8-25 years and groups did not differ in mean age or gender. Follow-up analyses were conducted to examine the role of antisocial behaviour (conduct problems) on FA and MD values in both groups. Comorbid ODD in ADHD was associated with lower FA in left frontotemporal WM, which appeared independent of ADHD symptoms. FA was negatively associated with antisocial behaviour in ADHD + ODD, but not in ADHD-only. Comorbid ODD is associated with WM abnormalities in individuals with ADHD, which appears to be independent of ADHD symptoms. Altered WM microstructure in comorbid ODD may play a role in inconsistencies in the current DTI literature in ADHD. Altered development of these tracts may contribute to social-emotional and cognitive problems in children with oppositional and antisocial behaviour.
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Registered trials
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