Evidence map›Paper›PMID 26507418›Full record

ReviewThe journal of physiological sciences : JPS2016

Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.

Tenpei Akita, Tatsuro Kumada, Sei-ichi Yoshihara, Joaquim Egea, Satoru Yamagishi

Open access · goldAbstract readReview
In one paragraph

Review in The journal of physiological sciences : JPS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  6. Extracellular NME proteins: a player or a bystander?Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Tenpei AkitaDepartment of Neurophysiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan. tenpak@hama-med.ac.jp.ORCID http://orcid.org/0000-0003-4614-4504
Tatsuro KumadaDepartment of Occupational Therapy, Faculty of Health and Medical Sciences, Tokoha University, 1230 Miyakoda-cho, Kita-ku, Hamamatsu, Shizuoka, 431-2102, Japan.
Sei-ichi YoshiharaLaboratory for Molecular Biology of Neural System, Advanced Medical Research Center, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Joaquim EgeaMolecular and Developmental Neurobiology Group, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, 25198, Lleida, Spain.
Satoru YamagishiDepartment of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Hamamatsu University School of Medicine · JPNara Medical University · JPTokoha Gakuen University · JPUniversitat de Lleida · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca(2+) and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.

Indexed as

AnimalsBlood VesselsCalciumIon ChannelsNervous SystemSignal TransductionTranscription FactorsCalciumIon ChannelsTranscription FactorsAnion channelAxon guidanceIntracellular signalingNervous system developmentTranscription factorVascular system development

Identifiers

PMID26507418
PMCPMC4752580
OpenAlexW2288351083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.