Evidence map›Paper›PMID 26507179›Full record

ArticleScientific reports2015

Fluorescence-Guided Probes of Aptamer-Targeted Gold Nanoparticles with Computed Tomography Imaging Accesses for in Vivo Tumor Resection.

Cheng-Hung Li, Tsung-Rong Kuo, Hsin-Jan Su, Wei-Yun Lai, Pan-Chyr Yang, Jinn-Shiun Chen, Di-Yan Wang, Yi-Chun Wu, Chia-Chun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 108 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Cheng-Hung LiDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Tsung-Rong KuoDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Hsin-Jan SuDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Wei-Yun LaiInstitute of Biomedical Sciences, Academia Sinica, Taipei 10617, Taiwan.
Pan-Chyr YangInstitute of Biomedical Sciences, Academia Sinica, Taipei 10617, Taiwan.
Jinn-Shiun ChenDivision of Colorectal Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33302, Taiwan.
Di-Yan WangDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
Yi-Chun WuInstitute of Molecular and Cell Biology, National Taiwan University, Taipei, 10617, Taiwan.
Chia-Chun ChenDepartment of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
National Taiwan Normal University · TWInstitute of Biomedical Sciences, Academia Sinica · TWChang Gung Memorial Hospital · TWInstitute of Atomic and Molecular Sciences, Academia Sinica · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent development of molecular imaging probes for fluorescence-guided surgery has shown great progresses for determining tumor margin to execute the tissue resection. Here we synthesize the fluorescent gold nanoparticles conjugated with diatrizoic acid and nucleolin-targeted AS1411 aptamer. The nanoparticle conjugates exhibit high water-solubility, good biocompatibility, visible fluorescence and strong X-ray attenuation for computed tomography (CT) contrast enhancement. The fluorescent nanoparticle conjugates are applied as a molecular contrast agent to reveal the tumor location in CL1-5 tumor-bearing mice by CT imaging. Furthermore, the orange-red fluorescence emitting from the conjugates in the CL1-5 tumor can be easily visualized by the naked eyes. After the resection, the IVIS measurements show that the fluorescence signal of the nanoparticle conjugates in the tumor is greatly enhanced in comparison to that in the controlled experiment. Our work has shown potential application of functionalized nanoparticles as a dual-function imaging agent in clinical fluorescence-guided surgery.

Indexed as

AnimalsCell Line, TumorContrast MediaFluorescenceFluorescent DyesGoldHumansMCF-7 CellsMetal NanoparticlesMiceMice, Inbred NODMice, SCIDMolecular ImagingMolecular ProbesNeoplasmsTomography, X-Ray ComputedContrast MediaFluorescent DyesGoldMolecular Probes

Identifiers

PMID26507179
PMCPMC4623475
OpenAlexW2408961314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.