Evidence map›Paper›PMID 26507168›Full record

ReviewNature reviews. Molecular cell biology2015

DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?

Guan-Zheng Luo, Mario Andres Blanco, Eric Lieberman Greer, Chuan He, Yang Shi

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Epigenetics and chromatin structure regulatebioRxiv : the preprint server for biology · 2026
    Article
  6. A PIWI protein-dependent DNA N6-adenine methylation pathway inbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Serum Folate and Vitamin BDiabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Shaping eukaryotic epigenetic systems by horizontal gene transfer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  20. Potential role of NiScience · 2023
    Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guan-Zheng LuoDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, and the Howard Hughes Medical Institute, 929 East 57th Street, Chicago, Illinois 60637, USA.
Mario Andres BlancoDepartment of Cell Biology, Harvard Medical School, and the Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Eric Lieberman GreerDivision of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, and the Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, and the Howard Hughes Medical Institute, 929 East 57th Street, Chicago, Illinois 60637, USA.
Yang ShiDepartment of Cell Biology, Harvard Medical School, and the Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

Funding

Labeling and sequencing of 5hmC and 5mC in DNA-RenewalR01HG006827 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2012 to 2025
$7.2M
Novel epigenetic mechanisms in neuronal development and cognitive functionR01MH096066 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ARLOTTA, PAOLA, POMEROY, SCOTT LOREN · 2012 to 2022
$6.1M
Histone Demethylases and Regulation of Chromatin and Transcription in EukaryotesR01CA118487 · NCI · HARVARD MEDICAL SCHOOL · PI SHI, YANG · 2006 to 2017
$3.6M
Identifying the molecular mechanisms of transgenerational epigenetic inheritanceR00AG043550 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2015 to 2017
$737k
Identifying the molecular mechanisms of transgenerational epigenetic inheritanceK99AG043550 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2013 to 2014
$269k
Howard Hughes Medical InstituteNCI NIH HHS CA118487NCI NIH HHS R01 CA118487NHGRI NIH HHS HG006827NHGRI NIH HHS R01 HG006827NIA NIH HHS AG043550NIA NIH HHS K99 AG043550NIA NIH HHS R00 AG043550NIMH NIH HHS MH096066NIMH NIH HHS R01 MH096066
6 · The paper itself

Abstract

DNA N(6)-adenine methylation (N(6)-methyladenine; 6mA) in prokaryotes functions primarily in the host defence system. The prevalence and significance of this modification in eukaryotes had been unclear until recently. Here, we discuss recent publications documenting the presence of 6mA in Chlamydomonas reinhardtii, Drosophila melanogaster and Caenorhabditis elegans; consider possible roles for this DNA modification in regulating transcription, the activity of transposable elements and transgenerational epigenetic inheritance; and propose 6mA as a new epigenetic mark in eukaryotes.

Indexed as

DNA MethylationEpigenesis, GeneticAdenineAnimalsCaenorhabditis elegansChlamydomonas reinhardtiiDNADNA Transposable ElementsDrosophila melanogasterGenetic MarkersPhylogenySite-Specific DNA-Methyltransferase (Adenine-Specific)Transcription, Genetic6-methyladenineAdenineDNADNA Transposable ElementsGenetic MarkersSite-Specific DNA-Methyltransferase (Adenine-Specific)

Identifiers

PMID26507168
PMCPMC4763336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.