Evidence map›Paper›PMID 26507133›Full record

Observational studyInfection2016

HCV-HIV coinfected pregnant women: data from a multicentre study in Italy.

S Baroncelli, M F Pirillo, R Amici, E Tamburrini, O Genovese, M Ravizza, A Maccabruni, G Masuelli, G Guaraldi, G Liuzzi and 7 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. CDC Recommendations for Hepatitis C Testing Among Perinatally Exposed Infants and Children - United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

S BaroncelliDepartment of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
M F PirilloDepartment of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
R AmiciDepartment of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
E TamburriniDepartment of Infectious Diseases, Catholic University, Rome, Italy.
O GenoveseDepartment of Paediatrics, Catholic University, Rome, Italy.
M RavizzaDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
A MaccabruniDepartment of Paediatrics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
G MasuelliDepartment of Obstetrics and Neonatology, Città della Salute e della Scienza Hospital, Universiy of Turin, Turin, Italy.
G GuaraldiDepartment of Medical Specialties, Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
G LiuzziI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
C PinnettiI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
V GiacometDepartment of Paediatrics, Luigi Sacco Hospital and University of Milan, Milan, Italy.
A Degli AntoniDepartment of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Parma, Italy.
A VimercatiDepartment of Obstetrics and Gynaecology and Policlinic Hospital, University of Bari, Bari, Italy.
S DalzeroDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
V SacchiDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
Marco FloridiaDepartment of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. floridia@iss.it.
Istituto Superiore di Sanità · ITUniversity of Milan · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITUniversità Cattolica del Sacro Cuore · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale di Parma · ITOspedale San Paolo · ITUniversity of Bari Aldo Moro · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide information about main pregnancy outcomes in HIV-HCV coinfected women and about the possible interactions between HIV and HCV in this particular population.

methodsData from a multicenter observational study of pregnant women with HIV, conducted in Italian University and Hospital Clinics between 2001 and 2015, were used. Eligibility criteria for analysis were HCV coinfection and at least one detectable plasma HCV-RNA viral load measured during pregnancy. Qualitative variables were compared using the Chi-square or the Fisher test and quantitative variables using the Mann-Whitney U test. The Spearman's coefficient was used to evaluate correlations between quantitative variables.

resultsAmong 105 women with positive HCV-RNA, median HCV viral load was substantially identical at the three trimesters (5.68, 5.45, and 5.86 log IU/ml, respectively), and 85.7 % of the women had at least one HCV-RNA value >5 log IU/ml. Rate of preterm delivery was 28.6 % with HCV-RNA <5 log IU/ml and 43.2 % with HCV-RNA >5log (p = 0.309). Compared to women with term delivery, women with preterm delivery had higher median HCV-RNA levels (third trimester: 6.00 vs. 5.62 log IU/ml, p = 0.037). Third trimester HIV-RNA levels were below 50 copies/ml in 47.7 % of the cases. No cases of vertical HIV transmission occurred. Rate of HCV transmission was 9.0 % and occurred only with HCV-RNA levels >5 log IU/ml.

conclusionsCoinfection with HIV and HCV has relevant consequences in pregnancy: HIV coinfection is associated with high HCV-RNA levels that might favour HCV transmission, and HCV infection might further increase the risk of preterm delivery in women with HIV. HCV/HIV coinfected women should be considered a population at high risk of adverse outcomes.

Indexed as

AdultCoinfectionFemaleHepacivirusHepatitis CHIV InfectionsHospitals, UniversityHumansInfant, NewbornItalyMalePregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature BirthRNA, ViralRNA, ViralHCVHCV-RNAHCV transmissionHIVHIV-RNAPregnancyPreterm delivery

Identifiers

PMID26507133
OpenAlexW2221958511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.