ArticleThe international journal of neuropsychopharmacology2016
A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First-Episode Psychosis.Acta psychiatrica Scandinavica · 2025Article
- The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review.Journal of clinical medicine · 2023Review
- Neutrophil to Lymphocyte Ratio in Patients With a First Episode of Psychosis: A Two-Year Longitudinal Follow-up Study.Schizophrenia bulletin · 2022Article
- The effect of early life events on glucose levels in first-episode psychosis.Frontiers in endocrinology · 2022Article
- The usefulness of Olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis.Psychopharmacology · 2021Article
- Prescribing pattern of antipsychotic medication for first-episode psychosis: a retrospective cohort study.BMJ open · 2021Article
- Identification ofFrontiers in pharmacology · 2021Article
- Clozapine Use in Patients with Early-Stage Schizophrenia in a Chinese Psychiatric Hospital.Neuropsychiatric disease and treatment · 2020Article
- Prescribing pattern of clozapine and other antipsychotics for patients with first-episode psychosis: a cross-sectional survey of early intervention teams.Therapeutic advances in psychopharmacology · 2017Article
- Risperidone-Induced Adverse Drug Reactions and Role ofJournal of pharmacology & pharmacotherapeuticsArticle
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 1 country.
Miquel BioqueBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Adrián LlerenaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Bibiana CabreraBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Gisela MezquidaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Antonio LoboBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Ana González-PintoBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Covadonga M Díaz-CanejaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Iluminada CorripioBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Eduardo J AguilarBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Antoni BulbenaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Josefina Castro-FornielesBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Eduard VietaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Amàlia LafuenteBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Sergi MasBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Mara ParelladaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Jerónimo Saiz-RuizBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Manuel J CuestaBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo).
Miguel BernardoBarcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, CIBERSAM, Barcelona, Spain (Drs Bioque, Cabrera, Mezquida, and Bernardo); CICAB-CAIBER Centro de Investigación Clínica, Hospital Universitario, Servicio Extremeño de Salud SES, Facultad de Medicina Universidad de Extremadura, CIBERSAM, Badajoz, Spain (Dr Llerena); Instituto de Investigación Sanitaria Aragón (IIS Aragón), University of Zaragoza, Zaragoza, Spain (Dr Lobo); Department of Psychiatry, Hospital Universitario de Alava, CIBERSAM, University of the Basque Country, Vitoria, Spain (Dr González-Pinto); Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain (Drs Díaz-Caneja and Parellada); Department of Psychiatry, Hospital de Sant Pau, CIBERSAM, Barcelona, Spain (Dr Corripio); Clinic Hospital Valencia, INCLIVA, CIBERSAM, Valencia University, Valencia, Spain (Dr Aguilar); Department of Psychiatry, Hospital del Mar, Barcelona, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (Dr Bulbena); Department of Child and Adolescent Psychiatry and Psychology, SGR-489, Neurosciences Institute, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Spain (Dr Castro-Fornieles); Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain (Dr Vieta); Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain (Drs Lafuente and Mas); Hospital Ramon y Cajal, Universidad de Alcala, IRYCIS, CIBERSAM, Madrid, Spain (Dr Saiz-Ruiz); Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Dr Cuesta); Universitat de Barcelona, IDIBAPS, Barcelona, Spain (Dr Bernardo). bernardo@clinic.ub.es.
PEPs GROUP
Complejo Hospitalario de Navarra · ESNavarre Institute of Health Research · ESHospital Clínic de Barcelona · ESInstituto de Investigación Sanitaria Aragón · ESHospital del Mar Research Institute · ESHospital de Sant Pau · ESHospital General Universitario Gregorio Marañón · ESINCLIVA Health Research Institute · ESUniversidad de Extremadura · ESUniversidad de Zaragoza · ESUniversitat de Barcelona · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe characterization of the first episode of psychosis and how it should be treated are principal issues in actual research. Realistic, naturalistic studies are necessary to represent the entire population of first episode of psychosis attended in daily practice.
methodsSixteen participating centers from the PEPs project recruited 335 first episode of psychosis patients, aged 7 to 35 years. This article describes and discusses the psychopharmacological interventions and safety profiles at baseline and during a 60-day pharmacovigilance period.
resultsThe majority of first episode of psychosis patients received a second-generation antipsychotic (96.3%), orally (95%), and in adjusted doses according to the product specifications (87.2%). A total of 24% were receiving an antipsychotic polytherapy pattern at baseline, frequently associated with lower or higher doses of antipsychotics than the recommended ones. Eight patients were taking clozapine, all in monotherapy. Males received higher doses of antipsychotic (P=.043). A total of 5.2% of the patients were being treated with long-acting injectable antipsychotics; 12.2% of the patients received anticholinergic drugs, 12.2% antidepressants, and 13.7% mood stabilizers, while almost 40% received benzodiazepines; and 35.52% reported at least one adverse drug reaction during the pharmacovigilance period, more frequently associated with higher antipsychotic doses and antipsychotic polytherapy (85.2% vs 45.5%, P<.001).
conclusionsThese data indicate that the overall pharmacologic prescription for treating a first episode of psychosis in Spain follows the clinical practice guideline recommendations, and, together with security issues, support future research of determinate pharmacological strategies for the treatment of early phases of psychosis, such as the role of clozapine, long-acting injectable antipsychotics, antipsychotic combination, and the use of benzodiazepines.
Indexed as
Acute DiseaseAdolescentAdultAntipsychotic AgentsChildFemaleHumansLogistic ModelsMalePharmacovigilancePolypharmacyPsychiatric Status Rating ScalesPsychotic DisordersSex FactorsSpainTreatment OutcomeAntipsychotic AgentsAntipsychoticfirst episode psychosispharmacovigilancepolytherapypsychotropic drugsschizophrenia.
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