ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015
Sex-Based Dissociation of White Matter Microstructure in Children With Attention-Deficit/Hyperactivity Disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis.Molecular psychiatry · 2023Pooled it
- White matter microstructure in children and adolescents with ADHD.NeuroImage. Clinical · 2022Pooled it
- Cerebellar network alterations in adult attention-deficit/hyperactivity disorder.Journal of psychiatry & neuroscience : JPNTrial
- Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder.Developmental medicine and child neurology · 2026Article
- Asymmetry of attentive networks contributes to adult Attention-deficit/hyperactivity disorder (ADHD) pathophysiology.European archives of psychiatry and clinical neuroscience · 2025Article
- Distinct structural brain network properties in children with familial versus non-familial attention-deficit/hyperactivity disorder (ADHD).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- ADHD-related sex differences in emotional symptoms across development.European child & adolescent psychiatry · 2024Article
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- ADHD-related sex differences in frontal lobe white matter microstructure and associations with response control under conditions of varying cognitive load and motivational contingencies.Brain imaging and behavior · 2023Article
- Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics.Journal of affective disorders · 2023Article
- Sex differences in atypical fronto-subcortical structural connectivity among children with attention-deficit/hyperactivity disorder: Associations with delay discounting.Behavioural brain research · 2023Article
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
- Multivariate associations between behavioural dimensions and white matter across children and adolescents with and without attention-deficit/hyperactivity disorder.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry.Experimental brain research · 2022Article
- Attention-deficit/hyperactivity disorder and white matter microstructure: the importance of dimensional analyses and sex differences.JCPP advances · 2022Article
- Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control.Developmental cognitive neuroscience · 2022Article
- Sex Effects on Mirror Overflow during Finger Tapping in Children with ADHD.Journal of the International Neuropsychological Society : JINS · 2022Article
- Beyond massive univariate tests: Covariance regression reveals complex patterns of functional connectivity related to attention-deficit/hyperactivity disorder, age, sex, and response control.Biological psychiatry global open science · 2022Article
- Developmental trajectory of subtle motor signs in attention-deficit/hyperactivity disorder: A longitudinal study from childhood to adolescence.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
- Response control correlates of anomalous basal ganglia morphology in boys, but not girls, with attention-deficit/hyperactivity disorder.Behavioural brain research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSexual dimorphism is evident in attention-deficit/hyperactivity disorder (ADHD), including subtype prevalence, adverse outcomes, and neural phenotype. Neurobiological studies of ADHD suggest that boys show more abnormalities in motor and premotor structure and function, whereas girls differ from typically developing (TD) peers in prefrontal circuitry. We applied diffusion tensor imaging (DTI) to identify ADHD-related sex-specific differences in motor/premotor and prefrontal white matter (WM) microstructure in children.
methodDTI estimated differences in WM microstructure among 120 children 8 to 12 years of age, 60 with ADHD (30 boys and 30 girls) and 60 controls (30 boys and 30 girls), matched on age, IQ, and handedness. Effects of diagnosis and sex on fractional anisotropy (FA) were assessed in motor/premotor and prefrontal regions. Group differences in FA and associations with response control (e.g., reaction time variability [CVRT] and commission error rate) were examined separately within sex.
resultsSex-by-diagnosis interactions were observed for FA in primary motor (M1) and medial orbitofrontal (MOFC) cortex. Post hoc tests revealed that boys with ADHD showed bilateral reductions in FA within M1, compared with TD peers; in contrast, girls with ADHD showed higher FA bilaterally within MOFC. Decreased M1 FA was associated with higher CVRT in boys and higher commission error rates in girls. For MOFC, lower FA was associated with greater CVRT and commission error rates across all participants with ADHD.
conclusionADHD affects the white matter of boys and girls differently; boys appear to be more affected in regions responsible for control of basic actions, whereas girls show more abnormalities in regions responsible for higher-level, top-down control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.