Evidence map›Paper›PMID 26506579›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2015

Randomized Clinical Trial of Family-Based Treatment and Cognitive-Behavioral Therapy for Adolescent Bulimia Nervosa.

Daniel Le Grange, James Lock, W Stewart Agras, Susan W Bryson, Booil Jo

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00879151 (Treatment of Bulimic Adolescents), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00879151 nacompletednot on this map

Treatment of Bulimic Adolescents

TypeinterventionalSponsorStanford UniversityRan2009 to 2014Enrolled130ConditionsBulimiaArmsCognitive Behavioral Therapy for Adolescents, Supportive Psychotherapy, Family Based Therapy for Bulimia Nervosa
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 239 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Neurocognitive Profiles and Predictors of Symptom Trajectory During and After Treatment in Adolescent Bulimia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Remission in adolescents with bulimia nervosa: Empirical evaluation of current conceptual models.European eating disorders review : the journal of the Eating Disorders Association · 2020
    Trial
  12. Rituals and preoccupations associated with bulimia nervosa in adolescents: Does motivation to change matter?European eating disorders review : the journal of the Eating Disorders Association · 2019
    Trial
  13. Trial
  14. Exploring Types of Family Environments in Youth with Eating Disorders.European eating disorders review : the journal of the Eating Disorders Association · 2017
    Trial
  15. Article
  16. Article
  17. Review
  18. Recent developments in treatments for eating disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel Le GrangeUniversity of California, San Francisco and The University of Chicago, IL (Emeritus). Electronic address: daniel.legrange@ucsf.edu.
James LockStanford University School of Medicine, Stanford, CA.
W Stewart AgrasStanford University School of Medicine, Stanford, CA.
Susan W BrysonStanford University School of Medicine, Stanford, CA.
Booil JoStanford University School of Medicine, Stanford, CA.
Stanford University · USUniversity of Chicago · US

Funding

1/2-Treatment of Bulimic AdolescentsR01MH079978 · NIMH · STANFORD UNIVERSITY · PI LOCK, JAMES D · 2008 to 2012
$2.2M
Mentoring and Research in Adolescent Eating DisordersK24MH074467 · NIMH · STANFORD UNIVERSITY · PI LOCK, JAMES D · 2005 to 2014
$1.9M
2/2-Treatment of Adolescent BulimicsR01MH079979 · NIMH · UNIVERSITY OF CHICAGO · PI LE GRANGE, DANIEL · 2008 to 2012
$1.5M
Treating Subthreshold Depression in Older Adults in Community-Based RehabR34MH079980 · NIMH · JEWISH HOME LIFECARE, MANHATTAN · PI REINHARDT, JOANN PATRICIA · 2008 to 2009
$541k
NIMH NIH HHS K24 MH074467NIMH NIH HHS R01 MH079978NIMH NIH HHS R01-MH-079978NIMH NIH HHS R01 MH079979NIMH NIH HHS R01-MH-079979NIMH NIH HHS R34 MH079980
6 · The paper itself

Abstract

objectiveThere is a paucity of randomized clinical trials (RCTs) for adolescents with bulimia nervosa (BN). Prior studies suggest cognitive-behavioral therapy adapted for adolescents (CBT-A) and family-based treatment for adolescent bulimia nervosa (FBT-BN) could be effective for this patient population. The objective of this study was to compare the relative efficacy of these 2 specific therapies, FBT-BN and CBT-A. In addition, a smaller participant group was randomized to a nonspecific treatment (supportive psychotherapy [SPT]), whose data were to be used if there were no differences between FBT-BN and CBT-A at end of treatment.

methodThis 2-site (Chicago and Stanford) randomized controlled trial included 130 participants (aged 12-18 years) meeting DSM-IV criteria for BN or partial BN (binge eating and purging once or more per week for 6 months). Outcomes were assessed at baseline, end of treatment, and 6 and 12 months posttreatment. Treatments involved 18 outpatient sessions over 6 months. The primary outcome was defined as abstinence from binge eating and purging for 4 weeks before assessment, using the Eating Disorder Examination.

resultsParticipants in FBT-BN achieved higher abstinence rates than in CBT-A at end of treatment (39% versus 20%; p = .040, number needed to treat [NNT] = 5) and at 6-month follow-up (44% versus 25%; p = .030, NNT = 5). Abstinence rates between these 2 groups did not differ statistically at 12-month follow-up (49% versus 32%; p = .130, NNT = 6).

conclusionIn this study, FBT-BN was more effective in promoting abstinence from binge eating and purging than CBT-A in adolescent BN at end of treatment and 6-month follow-up. By 12-month follow-up, there were no statistically significant differences between the 2 treatments. CLINICAL TRIAL REGISTRATION INFORMATION: Study of Treatment for Adolescents With Bulimia Nervosa; http://clinicaltrials.gov/; NCT00879151.

Indexed as

Cognitive Behavioral TherapyFamily TherapyAdolescentBulimiaBulimia NervosaCognitionDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleTreatment OutcomeUnited Statesadolescent medicinebulimia nervosacognitive-behavioral therapyeating disordersfamily-based treatment

Identifiers

PMID26506579
PMCPMC4624104
OpenAlexW1958455633

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.