ArticlePLoS neglected tropical diseases2015
A Comparative Study of Peripheral Immune Responses to Taenia solium in Individuals with Parenchymal and Subarachnoid Neurocysticercosis.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Taenia solium neurocysticercosis: Its current epidemiological, diagnostic, therapeutic, and control landscapes.PLoS neglected tropical diseases · 2026Review
- Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis.Open forum infectious diseases · 2025Article
- Adrenergic signaling during parasitic infections.Frontiers in immunology · 2025Review
- Transcriptomic analysis of subarachnoid cysts of Taenia solium reveals mechanisms for uncontrolled proliferation and adaptations to the microenvironment.Scientific reports · 2024Article
- Low responsiveness of peripheral lymphocytes in extraparenchymal neurocysticercosis.PLoS neglected tropical diseases · 2023Article
- The Local Inflammatory Profile and Predictors of Treatment Success in Subarachnoid Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.PLoS neglected tropical diseases · 2021Article
- Old friends meet a new foe: A potential role for immune-priming parasites in mitigating COVID-19 morbidity and mortality.Evolution, medicine, and public health · 2020Review
- In vitro model of postoncosphere development, and in vivo infection abilities of Taenia solium and Taenia saginata.PLoS neglected tropical diseases · 2019Article
- Perfusion magnetic resonance imaging in differentiation of neurocysticercosis and tuberculoma.Neuroradiology · 2019Article
- Antibody Banding Patterns of the Enzyme-Linked Immunoelectrotransfer Blot and Brain Imaging Findings in Patients With Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.PLoS neglected tropical diseases · 2017Article
- Regulation of the host immune system by helminth parasites.The Journal of allergy and clinical immunology · 2016Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe ability of Taenia solium to modulate the immune system likely contributes to their longevity in the human host. We tested the hypothesis that the nature of the immune response is related to the location of parasite and clinical manifestations of infection. METHODOLOGY: Peripheral blood mononuclear cells (PBMC) were obtained from untreated patients with neurocysticercosis (NCC), categorized as having parenchymal or subarachnoid infection by the presence of cysts exclusively within the parenchyma or in subarachnoid spaces of the brain, and from uninfected (control) individuals matched by age and gender to each patient. Using multiplex detection technology, sera from NCC patients and controls and cytokine production by PBMC after T. solium antigen (TsAg) stimulation were assayed for levels of inflammatory and regulatory cytokines. PBMC were phenotyped by flow cytometry ex vivo and following in vitro stimulation with TsAg. PRINCIPAL
findingsSera from patients with parenchymal NCC demonstrated significantly higher Th1 (IFN-γ/IL-12) and Th2 (IL-4/IL-13) cytokine responses and trends towards higher levels of IL-1β/IL-8/IL-5 than those obtained from patients with subarachnoid NCC. Also higher in vitro antigen-driven TNF-β secretion was detected in PBMC supernatants from parenchymal than in subarachnoid NCC. In contrast, there was a significantly higher IL-10 response to TsAg stimulation in patients with subarachnoid NCC compared to parenchymal NCC. Although no differences in regulatory T cells (Tregs) frequencies were found ex vivo, there was a trend towards greater expansion of Tregs upon TsAg stimulation in subarachnoid than in parenchymal NCC when data were normalized for the corresponding controls. CONCLUSIONS/SIGNIFICANCE: T. solium infection of the subarachnoid space is associated with an enhanced regulatory immune response compared to infection in the parenchyma. The resulting anti-inflammatory milieu may represent a parasite strategy to maintain a permissive environment in the host or diminish inflammatory damage from the host immune response in the central nervous system.
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