ArticleViruses2015
Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France.
Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- A Fatal Case of Puumala Virus Infection with Pulmonary and Renal Syndrome in Moscow Region, Russia.Pathogens (Basel, Switzerland) · 2026Article
- Nephropathia Epidemica Caused by Puumala Virus in Bank Voles, Scania, Southern Sweden.Emerging infectious diseases · 2024Article
- Tropism ofViruses · 2023Article
- Article
- Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains.Archives of virology · 2021Article
- Puumala Virus Variants Circulating in Forests of Ardennes, France: Ten Years of Genetic Evolution.Pathogens (Basel, Switzerland) · 2021Article
- Impact of Landscape on Host-Parasite Genetic Diversity and Distribution Using theMicroorganisms · 2021Article
- Isolation and Genetic Characterization of Puumala Orthohantavirus Strains from France.Pathogens (Basel, Switzerland) · 2021Article
- Hantavirus-Epidemiology and infection · 2021Article
- How Bank Vole-PUUV Interactions Influence the Eco-Evolutionary Processes Driving Nephropathia Epidemica Epidemiology-An Experimental and Genomic Approach.Pathogens (Basel, Switzerland) · 2020Article
- Orthohantaviruses, Emerging Zoonotic Pathogens.Pathogens (Basel, Switzerland) · 2020Review
- Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica.Pathogens (Basel, Switzerland) · 2020Article
- Revisiting the genetic diversity of emerging hantaviruses circulating in Europe using a pan-viral resequencing microarray.Scientific reports · 2019Article
- Prediction of the Spatial Origin of Puumala Virus Infections Using L Segment Sequences Derived from a Generic Screening PCR.Viruses · 2019Article
- Phylogeography of Puumala orthohantavirus in Europe.Viruses · 2019Article
- Puumala Hantavirus Genotypes in Humans, France, 2012-2016.Emerging infectious diseases · 2019Article
- Identifying the patterns and drivers ofVirus evolution · 2019Article
- Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans?Epidemiology and infection · 2017Article
- Host-Associated Absence of Human Puumala Virus Infections in Northern and Eastern Germany.Emerging infectious diseases · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE or in area from where no NE case has been reported until now. Bank voles were tested for immunoglobulin (Ig)G ELISA serology and two seropositive animals for each of three different areas (Ardennes, Jura and Orleans) were then subjected to laboratory analyses in order to sequence the whole S, M and L segments of PUUV. Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Sequence analyses revealed specific amino acid signatures along the N protein, including in PUUV from the Orleans region from where NE in humans has never been reported. The relevance of these mutations in term of pathophysiology is discussed.
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