An Arresting Story about Basement Membrane Invasion.

Andrew J Ewald

Abstract readComment

In one paragraph

Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor.Integrative biology : quantitative biosciences from nano to macro · 2021
Article

4 · The record

Corrections and comments

Comment on
Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.2015

5 · Who and what money

Authors and funding

1 author.

Andrew J EwaldDepartments of Cell Biology, Oncology, and Biomedical Engineering, School of Medicine, Johns Hopkins University, 855 N. Wolfe Street, Rangos 452, Baltimore, MD 21205, USA. Electronic address: andrew.ewald@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Developmental Cell, Matus et al. (2015) reveal that to invade past basement membrane, the C. elegans anchor cell must cease dividing before differentiating and expressing pro-invasion genes. This demonstration of invasion and proliferation as mutually incompatible cell states has implications for our understanding of cancer metastasis.

Indexed as

AnimalsCaenorhabditis elegans ProteinsCell DifferentiationG1 Phase Cell Cycle CheckpointsHistone DeacetylasesNeoplasm InvasivenessCaenorhabditis elegans ProteinsHistone Deacetylases

Identifiers

PMID26506303

DOI10.1016/j.devcel.2015.10.009

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.